0104 areas
VPAC1 and VPAC2 signaling
VIP's two G protein-coupled receptors, shared with PACAP.
Optimum ReGen Peptides21+
Research use only
All research products on this site, including all peptides, are sold strictly for laboratory and research use only, not for human or animal consumption, diagnostic, or therapeutic use. Our tallow skincare products are topical cosmetics. You must be 21 or older to enter.
Third-party testedHPLC + MSMedford, OR
By entering you confirm you are 21+ and accept these products are for research use only. See our Terms and Disclaimer.
VIP Peptide (Vasoactive Intestinal Peptide)
Twenty-eight amino acids, amidated, lyophilized. Sold in 5mg vials for laboratory research.
$40.00
$5020% off
In stock2-Day Priority Air anywhere in the US
Choose your size
Savings per mg compared with the 5mg size.
1
Secure checkout2-Day Priority Air
Complete the order
Frequently bought together
Supplies and compounds researchers add to this order
Finding add-ons…
Shipping & returns
- 2-Day Priority Air: $13 flat anywhere in the US, or pick up in Medford.
- Tracking is emailed the moment your order ships.
- Research compounds are final sale; see the refund policy.
Lab sheet
VIP details
Identity, purity and handling data for this compound, in one place. Tap an identifier to copy it.
Molecular Formula
C147H237N43O43S
Molar Mass
3326.8 g/mol
CAS Number
40077-57-4
Amino Acids
28
Form
Lyophilized powder
Amino acid sequence
28 residues·Tap a residue
chargedpolarhydrophobicglycine / proline
Full data sheet+
- Purity
- A batch report is not published for this product. Contact ORP before ordering if you need one.
- Synonyms
- Vasoactive intestinal peptide, vasoactive intestinal polypeptide, aviptadil
- PubChem CID
- 16132300
- Storage (lyophilized)
- -20 °C, sealed, light-protected
For research use only. Not for human consumption.
Overview
About VIP
VIP, vasoactive intestinal peptide, is a 28-amino-acid neuropeptide made by nerve cells in the gut, brain and other tissues. It belongs to the secretin and glucagon family of peptide hormones and is closely related to PACAP. VIP is a standard tool in research on smooth muscle, blood vessels, circadian timing and immune signaling.
Read moreShow less
It has 28 amino acids (HSDAVFTDNYTRLRKQMAVKKYLNSILN, with an amidated C-terminus), a molecular formula of C147H237N43O43S, a molar mass of 3326.8 g/mol and CAS number 40077-57-4; the full identifiers are in the lab sheet above. ORP supplies it as a lyophilized powder for in vitro and preclinical research only. It is not for human or animal use and is not intended to diagnose, treat, cure, or prevent any disease.
Sami Said and Viktor Mutt isolated VIP from porcine small intestine in 1970, reporting it in Nature as a potent vasodilator from the gut and in Science as a polypeptide with broad biological activity. Human, pig and rat VIP share the same sequence.
VIP acts on two G protein-coupled receptors, VPAC1 and VPAC2, which it shares with PACAP; a third receptor, PAC1, responds mainly to PACAP. The International Union of Pharmacology standardized these names in 1998.
Research lines include circadian timing, where a 2005 study in Nature Neuroscience showed that VIP signaling mediates rhythmicity and synchrony among clock neurons of the suprachiasmatic nucleus, and immune signaling, where a 2001 study in Nature Medicine reported that VIP reduced the autoimmune and inflammatory components of experimental arthritis in mice. Synthetic VIP also has an international nonproprietary name, aviptadil.
Researchers usually confirm identity against the sequence and a molar mass of about 3,327 by mass spectrometry, and purity by HPLC. A third-party certificate of analysis is not published here for this product; contact ORP before ordering if your work needs particular identity or purity tests.
Research context
What VIP is researched for
The areas where this compound appears in the published research literature.
Methodology
How VIP is studied
01Method 1Published VIP work uses receptor-binding and cAMP signaling assays in cells expressing VPAC1 or VPAC2, isolated smooth-muscle and vascular preparations,…+
Published VIP work uses receptor-binding and cAMP signaling assays in cells expressing VPAC1 or VPAC2, isolated smooth-muscle and vascular preparations, brain-slice recordings of clock neurons, and rodent models of inflammation, with readouts such as receptor activation, vascular tone and cytokine levels.
02Method 2Identity is confirmed against the sequence and its molar mass by mass spectrometry, and purity by HPLC.+
Identity is confirmed against the sequence and its molar mass by mass spectrometry, and purity by HPLC. Each research protocol sets its own model, controls, concentrations and handling; this listing supplies the compound, not a protocol.
Storage protocols
VIP storage and handling
Lyophilized
-20°C
Long-term storage, as supplied
Reconstituted
2-8°C
In solution
Full handling protocol+
Store lyophilized VIP at -20°C, sealed and protected from light and moisture. Let the vial reach room temperature before opening so moisture does not condense on the powder.
Reconstituted peptide solutions are commonly held at 2-8°C and divided into single-use aliquots to avoid repeated freeze-thaw cycles. Validate the solvent, concentration and use period for your own protocol.
Ordering & shipping
Buy VIP online
VIP for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $50. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
VIP is supplied as lyophilized powder, for laboratory and research use only, not for human consumption.
FAQ
VIP FAQ
What is VIP?
VIP, vasoactive intestinal peptide, is a 28-amino-acid neuropeptide that acts on the receptors VPAC1 and VPAC2. It is studied in vascular, circadian and immune research. ORP sells it for laboratory research only.
What is the VIP amino acid sequence?
HSDAVFTDNYTRLRKQMAVKKYLNSILN, with an amidated C-terminus: 28 residues, molecular formula C147H237N43O43S, molar mass 3326.8 g/mol.
What is the CAS number for VIP?
40077-57-4. Its PubChem compound ID is 16132300.
What receptors does VIP bind?
VPAC1 and VPAC2, two G protein-coupled receptors it shares with the related peptide PACAP.
Is VIP the same as aviptadil?
Aviptadil is the international nonproprietary name for synthetic VIP with the native sequence. This listing is the native 28-amino-acid peptide for laboratory research.
What does VIP research study?
Mainly receptor signaling through VPAC1 and VPAC2, vascular and smooth-muscle responses, circadian timing in the suprachiasmatic nucleus, and immune and inflammatory signaling in animal models. All of this is laboratory research.
Is this VIP third-party tested?
A third-party certificate of analysis is not published for this product. Contact ORP before ordering if your work needs particular identity or purity tests.
How should VIP be stored?
Keep the lyophilized powder at -20°C, sealed and protected from light and moisture. Reconstituted solutions are commonly kept at 2-8°C in single-use aliquots; validate the use period for your own protocol.
Is VIP for human use?
No. ORP sells VIP strictly as a laboratory research compound, not for human or animal consumption, and it is not intended to diagnose, treat, cure, or prevent any disease.
Research library