0105 areas
Telomere and telomerase biology
Telomerase catalytic subunit expression, telomerase activity and telomere length in cultured human cells.
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Epithalon Peptide (Epitalon, AEDG)
A four-amino-acid peptide, Ala-Glu-Asp-Gly, lyophilized. Sold as 10mg vials and a 100mg kit for laboratory research.
$27.60
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- 2-Day Priority Air: $13 flat anywhere in the US, or pick up in Medford.
- Tracking is emailed the moment your order ships.
- Research compounds are final sale; see the refund policy.
Lab sheet
Epithalon details
Identity, purity and handling data for this compound, in one place. Tap an identifier to copy it.
Certificate of analysis
Not published yet
A third-party certificate for Epithalon is not published here yet. If your work needs one, ask us before ordering and we will tell you what testing is available for the current lot.
Ask about a certificateMolecular Formula
C14H22N4O9
Molar Mass
390.35 g/mol
CAS Number
307297-39-8
Amino Acids
4
Form
Lyophilized powder
Amino acid sequence
4 residues·Tap a residue
chargedpolarhydrophobicglycine / proline
Full data sheet+
- Purity
- A batch report is not published for every lot. Contact ORP before ordering if you need one.
- Synonyms
- Epitalon, Epithalone, AEDG peptide, Ala-Glu-Asp-Gly
- PubChem CID
- 219042
- Storage (lyophilized)
- -20 °C, sealed, light-protected
For research use only. Not for human consumption.
Overview
About Epithalon
Epithalon is one of the shortest peptides in research use: just four amino acids, Ala-Glu-Asp-Gly. It is best known from cell-culture studies of telomeres and telomerase, and from research on the pineal gland, which is where its parent extract came from.
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Its molar mass is 390.35 g/mol and its CAS number is 307297-39-8; the full identifiers are in the lab sheet above. ORP supplies it as a lyophilized powder for in vitro and preclinical research only. It is not for human or animal use and is not intended to diagnose, treat, cure, or prevent any disease.
The peptide comes from the research group of Vladimir Khavinson in St. Petersburg, which studied epithalamin, a polypeptide extract of bovine pineal gland. Epithalon was synthesized from the amino acid composition of that extract, giving researchers a single, chemically defined four-residue peptide to work with in place of a complex mixture. A 2025 review in the International Journal of Molecular Sciences summarizes about 25 years of in vitro, in vivo and in silico work on it, and notes that physical and structural studies of the peptide itself remain limited.
Epithalon is best known in telomere research. In a 2003 study, adding it to cultures of telomerase-negative human fetal fibroblasts was reported to induce expression of the telomerase catalytic subunit, telomerase activity, and telomere elongation. A 2004 follow-up from the same group used aging human fetal lung fibroblasts and reported telomere elongation and continued cell division beyond the point where control cultures stopped dividing. These are observations in cultured cells from one research group, not evidence of any effect of this product.
Other research areas covered in the literature include the pineal gland and melatonin synthesis, changes in interleukin-2 mRNA, the mitogenic activity of mouse thymocytes, and the activity of enzymes such as acetylcholinesterase, butyrylcholinesterase and telomerase. The 2025 review describes these as possible mechanisms and says it remains uncertain whether they are the whole picture, which is why Epithalon is used as a tool compound in aging biology and neuroendocrine research rather than studied as a single-mechanism peptide.
Because it is short and fully defined, Epithalon's identity is straightforward to check: researchers compare a sample against the sequence AEDG and a molar mass of about 390 by mass spectrometry, and assess purity by HPLC. A third-party certificate of analysis is not published here for every lot; contact ORP before ordering if your work needs particular identity or purity tests.
Research context
What Epithalon is researched for
The areas where this compound appears in the published research literature.
Methodology
How Epithalon is studied
01Method 1Published Epithalon work uses cultured human cells, such as fetal fibroblasts, and animal models.+
Published Epithalon work uses cultured human cells, such as fetal fibroblasts, and animal models. Typical readouts are telomerase expression and activity, telomere length, cell division in culture, melatonin, and enzyme activity.
02Method 2Identity is confirmed against the sequence AEDG and its molar mass by mass spectrometry, and purity by HPLC.+
Identity is confirmed against the sequence AEDG and its molar mass by mass spectrometry, and purity by HPLC. Each research protocol sets its own model, controls, concentrations and handling; this listing supplies the compound, not a protocol.
Storage protocols
Epithalon storage and handling
Lyophilized
-20°C
Long-term storage, as supplied
Reconstituted
2-8°C
In solution
Full handling protocol+
Store lyophilized Epithalon at -20°C, sealed and protected from light and moisture. Let the vial reach room temperature before opening so moisture does not condense on the powder.
Reconstituted peptide solutions are commonly held at 2-8°C and divided into single-use aliquots to avoid repeated freeze-thaw cycles. Validate the solvent, concentration and use period for your own protocol.
Ordering & shipping
Buy Epithalon online
Epithalon (Epitalon) for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $40. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
Epithalon is supplied as lyophilized powder, for laboratory and research use only, not for human consumption.
FAQ
Epithalon FAQ
What is Epithalon?
Epithalon is a synthetic four-amino-acid peptide, Ala-Glu-Asp-Gly (AEDG), based on the amino acid composition of epithalamin, a bovine pineal gland extract. It is studied in telomere biology, cellular aging and pineal research in cell and animal models. ORP sells it for laboratory research only.
Is it Epithalon or Epitalon?
Both. Epithalon, Epitalon and Epithalone are spellings of the same peptide, AEDG, CAS 307297-39-8. Suppliers and papers use them interchangeably.
What is the Epithalon amino acid sequence?
Ala-Glu-Asp-Gly, written AEDG in one-letter code. It has four residues, molecular formula C14H22N4O9 and a molar mass of 390.35 g/mol.
What is the CAS number for Epithalon?
307297-39-8. Its PubChem compound ID is 219042.
Is Epithalon the same as epithalamin?
No. Epithalamin is a complex polypeptide extract of bovine pineal gland. Epithalon is a single synthetic tetrapeptide made from that extract's amino acid composition, so it is chemically defined where the extract is a mixture.
How does Epithalon relate to telomerase research?
In a 2003 cell-culture study, adding Epithalon to telomerase-negative human fetal fibroblasts was reported to induce telomerase expression and activity and telomere elongation. A 2004 follow-up reported continued division of aging fetal lung fibroblasts. Both are laboratory observations in cultured cells.
Who developed Epithalon?
The research group of Vladimir Khavinson in St. Petersburg, Russia, which studied pineal gland peptide extracts and published much of the early Epithalon literature.
Is this Epithalon third-party tested?
A third-party certificate of analysis is not published for every lot. Contact ORP before ordering if your work needs particular identity or purity tests.
How should Epithalon be stored?
Keep the lyophilized powder at -20°C, sealed and protected from light and moisture. Reconstituted solutions are commonly kept at 2-8°C in single-use aliquots; validate the use period for your own protocol.
Is Epithalon for human use?
No. Epithalon is not approved for any clinical use, and ORP sells it strictly as a laboratory research compound, not for human or animal consumption.
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