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For laboratory research. Sold in 500mg and 5,000mg kit sizes.
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For research use only. Not for human consumption.
NAD+ 500 (nicotinamide adenine dinucleotide, 500 mg formulation) provides research-grade NAD+ for laboratory investigation of cellular energy metabolism, mitochondrial function, and the diverse enzymatic reactions in which NAD+ serves as a critical coenzyme. NAD+ is a fundamental molecule in cellular biochemistry, functioning both as a hydride carrier in oxidation-reduction reactions and as a substrate for enzymes including sirtuins, PARPs, and CD38.
Research interest in NAD+ has grown substantially with the recognition that NAD+ levels decline with age in many tissue models and that restoring NAD+ availability influences a range of cellular processes including mitochondrial biogenesis, DNA repair, and inflammatory signaling. Laboratory studies use NAD+ preparations to investigate these pathways in cell culture and preclinical models.
Research-grade NAD+ 500 is utilized as a direct substrate in enzymatic assays, as a supplementation agent in cell culture experiments studying metabolic rescue, and in biochemical studies examining NAD+/NADH ratios and their relationship to cellular redox state and signaling.
The areas where this compound appears in the published research literature.
In laboratory research, NAD+ is added to cell culture media or administered in preclinical animal models to examine the metabolic consequences of altered NAD+ availability. Researchers quantify intracellular NAD+ and NADH levels using cycling-based colorimetric assays or LC-MS/MS, and measure downstream pathway activity through sirtuin deacetylase assays, PARP activity assays, and mitochondrial respiration measurements via Seahorse XF analysis.
In vitro enzymatic studies use purified recombinant enzymes (sirtuins, PARPs, CD38) with NAD+ as the substrate to characterize kinetic parameters (Km, Vmax) and inhibitor profiles, providing fundamental biochemical data on how these enzymes interact with the NAD+ molecule.
Aging research models use NAD+ supplementation in aged cell lines or tissues to examine whether restoring NAD+ availability can reverse age-associated changes in mitochondrial function, gene expression, or cellular stress responses, contributing to our mechanistic understanding of the relationship between NAD+ and cellular aging.
Research-grade NAD+ powder should be stored at -20 °C in a sealed, moisture-proof container away from direct light. NAD+ is hygroscopic and sensitive to oxidation; exposure to air, light, or elevated temperature will accelerate degradation. Lyophilized material stored under dry, cold conditions is stable for extended periods.
Reconstituted NAD+ solutions should be prepared in cold, neutral-pH buffer (typically PBS, pH 7.4) and used within the experimental session when possible. If storage of reconstituted material is necessary, aliquot into single-use volumes and store at -80 °C; avoid repeated freeze-thaw cycling as NAD+ in solution is prone to hydrolytic degradation.
NAD+ (Nicotinamide Adenine Dinucleotide) for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $70. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
The current batch has a published third-party certificate of analysis, shown above. NAD+ is supplied as lyophilized powder, for laboratory and research use only, not for human consumption.
