0104 areas
Vascular endothelial cells
Proliferation (Ki-67) in endothelial cultures from young and old animals.
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Vesugen Peptide (KED Tripeptide)
Three amino acids, H-Lys-Glu-Asp-OH, lyophilized. Sold in 10mg vials for laboratory research.
$48.00
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Lab sheet
Vesugen details
Identity, purity and handling data for this compound, in one place. Tap an identifier to copy it.
Molecular Formula
C15H26N4O8
Molar Mass
390.4 g/mol
CAS Number
204271-66-9
Amino Acids
3
Form
Lyophilized powder
Amino acid sequence
3 residues·Tap a residue
chargedpolarhydrophobicglycine / proline
Full data sheet+
- Purity
- A batch report is not published for this product. Contact ORP before ordering if you need one.
- Synonyms
- Lys-Glu-Asp, KED, lysyl-glutamyl-aspartic acid
- PubChem CID
- 87571363
- Storage (lyophilized)
- -20 °C, sealed, light-protected
For research use only. Not for human consumption.
Overview
About Vesugen
Vesugen is a synthetic tripeptide, Lys-Glu-Asp (KED). It belongs to a family of short peptides, two to four amino acids long, that Vladimir Khavinson's group at the St. Petersburg Institute of Bioregulation and Gerontology studies for their effects on gene expression in cell-culture models of aging, here with a focus on blood-vessel cells.
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It has 3 amino acids (H-Lys-Glu-Asp-OH), a molecular formula of C15H26N4O8, a molar mass of 390.4 g/mol and CAS number 204271-66-9; the full identifiers are in the lab sheet above. ORP supplies it as a lyophilized powder for in vitro and preclinical research only. It is not for human or animal use and is not intended to diagnose, treat, cure, or prevent any disease.
In a 2014 study in Advances in Gerontology, Vesugen raised levels of the proliferation marker Ki-67, which falls with age, in vascular endothelial cell cultures from young and old animals. A 2012 study in the Bulletin of Experimental Biology and Medicine reported that it stimulated expression of differentiation factors in fibroblasts, more strongly in aged cultures.
A 2021 study in Pharmaceuticals examined KED and the related tripeptide EDR in a mouse model of Alzheimer's disease, building on cell-model work in which both prevented amyloid-related loss of dendritic spines. A 2020 study in Molecular Biology Reports tested KED alongside AED and KE on aging-related genes such as TERT and FOXO1 in human mesenchymal stem cells.
Almost all published work on KED comes from this one research group and uses cell-culture and animal models, so independent replication is limited. Related peptides in this catalog from the same research program are Cartalax (Ala-Glu-Asp) and Epithalon (Ala-Glu-Asp-Gly).
Researchers usually confirm identity against the sequence and a molar mass of about 390 by mass spectrometry, and purity by HPLC. A third-party certificate of analysis is not published here for this product; contact ORP before ordering if your work needs particular identity or purity tests.
Research context
What Vesugen is researched for
The areas where this compound appears in the published research literature.
Methodology
How Vesugen is studied
01Method 1Published KED work uses vascular endothelial, fibroblast, mesenchymal stem cell and neuronal cultures, often comparing young and aged cells, plus mouse models,…+
Published KED work uses vascular endothelial, fibroblast, mesenchymal stem cell and neuronal cultures, often comparing young and aged cells, plus mouse models, with gene-expression, protein-marker and dendritic-spine readouts.
02Method 2Identity is confirmed against the sequence H-Lys-Glu-Asp-OH and its molar mass by mass spectrometry, and purity by HPLC.+
Identity is confirmed against the sequence H-Lys-Glu-Asp-OH and its molar mass by mass spectrometry, and purity by HPLC. Each research protocol sets its own model, controls, concentrations and handling; this listing supplies the compound, not a protocol.
Storage protocols
Vesugen storage and handling
Lyophilized
-20°C
Long-term storage, as supplied
Reconstituted
2-8°C
In solution
Full handling protocol+
Store lyophilized Vesugen at -20°C, sealed and protected from light and moisture. Let the vial reach room temperature before opening so moisture does not condense on the powder.
Reconstituted peptide solutions are commonly held at 2-8°C and divided into single-use aliquots to avoid repeated freeze-thaw cycles. Validate the solvent, concentration and use period for your own protocol.
Ordering & shipping
Buy Vesugen online
Vesugen for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $60. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
Vesugen is supplied as lyophilized powder, for laboratory and research use only, not for human consumption.
FAQ
Vesugen FAQ
What is Vesugen?
Vesugen is the synthetic tripeptide Lys-Glu-Asp (KED), studied in cell-culture research on vascular endothelial cells and gene expression in aging cells. ORP sells it for laboratory research only.
What is the Vesugen amino acid sequence?
Lys-Glu-Asp, written H-Lys-Glu-Asp-OH or KED: three residues, molecular formula C15H26N4O8, molar mass 390.4 g/mol.
What is the CAS number for Vesugen?
204271-66-9. Its PubChem compound ID is 87571363.
How is Vesugen related to Cartalax and Epithalon?
All three come from the same short-peptide research program. Vesugen is Lys-Glu-Asp (KED), Cartalax is Ala-Glu-Asp (AED) and Epithalon is Ala-Glu-Asp-Gly (AEDG).
What does Vesugen research study?
Mainly blood-vessel and aging cell models: proliferation of vascular endothelial cells, differentiation factors in fibroblasts, aging-related genes in stem cells, and neuronal models of Alzheimer's disease. All of this is laboratory research in cell and animal models.
Who has studied Vesugen?
Most published KED studies come from Vladimir Khavinson's group at the St. Petersburg Institute of Bioregulation and Gerontology, so independent replication is limited.
Is this Vesugen third-party tested?
A third-party certificate of analysis is not published for this product. Contact ORP before ordering if your work needs particular identity or purity tests.
How should Vesugen be stored?
Keep the lyophilized powder at -20°C, sealed and protected from light and moisture. Reconstituted solutions are commonly kept at 2-8°C in single-use aliquots; validate the use period for your own protocol.
Is Vesugen for human use?
No. ORP sells Vesugen strictly as a laboratory research compound, not for human or animal consumption, and it is not intended to diagnose, treat, cure, or prevent any disease.
Research library