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For laboratory research. Sold in 30mg, 30mg x 2 and 300mg kit sizes.
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For research use only. Not for human consumption.
ORP-2(TR) is a synthetic 39-amino acid peptide that functions as a dual agonist at the glucagon-like peptide-1 receptor (GLP-1R) and the glucose-dependent insulinotropic polypeptide receptor (GIPR). Its design incorporates a fatty diacid moiety via a linker at lysine-26 to enable albumin binding and extend the half-life to approximately five days, supporting once-weekly administration in clinical study protocols.
The dual incretin mechanism of ORP-2(TR) has attracted broad research interest because GIP and GLP-1 receptors are co-expressed in key metabolic tissues including pancreatic islets, adipose tissue, and the central nervous system. Preclinical and clinical research has investigated how simultaneous agonism of both receptors influences insulin secretion, glucagon suppression, gastric emptying, adipogenesis, and body weight regulation differently from selective GLP-1 receptor agonists.
As a research compound, ORP-2(TR) is studied to better understand the biology of the incretin system and the metabolic consequences of dual GIPR/GLP-1R engagement. It is provided for laboratory research use only and is not supplied for therapeutic administration outside of formally regulated clinical contexts.
The areas where this compound appears in the published research literature.
In cell-based assays, ORP-2(TR) is applied to GLP-1R- or GIPR-expressing cell lines at picomolar to nanomolar concentrations. Researchers measure cAMP accumulation using HTRF or ELISA-based assays, cell-surface receptor expression by flow cytometry, and downstream phosphorylation events by immunoblot to construct mechanistic pharmacology profiles.
Preclinical mouse and rat models of diet-induced obesity and type 2 diabetes have been used to study ORP-2(TR)'s effects on fasting and postprandial glucose, HbA1c-equivalent endpoints, body weight, adiposity, and liver steatosis markers. These studies often include pair-feeding controls and receptor-selective agonist comparators to dissect GLP-1R versus GIPR contributions.
Pharmacokinetic studies characterize ORP-2(TR)'s plasma half-life, albumin binding fraction, volume of distribution, and metabolite profile. Mass spectrometry-based methods are used to quantify intact ORP-2(TR) and its degradation products in plasma samples from preclinical models, informing experimental protocol design.
Store lyophilized ORP-2(TR) at -20 C or below, protected from light and humidity. The lyophilized form is stable for extended periods under these conditions. Reconstitute in sterile saline or bacteriostatic water using aseptic technique. Store reconstituted solutions at 4 C for short-term use or aliquot and freeze at -80 C to minimize degradation. Avoid repeated freeze-thaw cycles, which can promote peptide aggregation and loss of activity. The fatty diacid-modified structure of ORP-2(TR) should be considered when selecting reconstitution buffers to ensure full solubilization. Maintain full chain-of-custody documentation per laboratory protocol.
ORP-2(TR) for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $150. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
The current batch has a published third-party certificate of analysis, shown above. ORP-2(TR) is supplied as lyophilized powder, for laboratory and research use only, not for human consumption.
