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For laboratory research. Sold in 5mg and 50mg sizes.
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For research use only. Not for human consumption.
AOD-9604 is a synthetic peptide fragment derived from the C-terminus of human growth hormone (hGH), specifically corresponding to amino acids 177-191. Researchers originally investigated this fragment as part of efforts to isolate the lipolytic activity of hGH without the proliferative or metabolic side effects associated with the full molecule.
In laboratory settings, AOD-9604 has been studied for its interactions with beta-3 adrenergic receptors, which play a role in adipocyte metabolism. Preclinical models have examined how this fragment influences fat cell mobilization and lipogenesis without measurable impact on insulin-like growth factor-1 (IGF-1) levels, distinguishing it mechanistically from intact growth hormone.
Research into AOD-9604 has also explored its cartilage and bone metabolism properties in animal models. Studies published in peer-reviewed journals have investigated its potential utility in musculoskeletal research contexts, making it a compound of ongoing scientific interest across metabolic and regenerative biology disciplines.
The areas where this compound appears in the published research literature.
In laboratory research, AOD-9604 is typically administered to cell cultures or animal models and assessed using lipolysis assays, which measure free fatty acid release from adipocytes. Researchers employ radioimmunoassay and ELISA techniques to monitor downstream hormonal markers, confirming that the fragment does not stimulate IGF-1 production as full hGH does.
Cartilage research employing AOD-9604 often uses ex vivo tissue explants or primary chondrocyte cultures, with outcomes measured through histological staining (safranin-O, toluidine blue) and proteoglycan quantification. Researchers compare treated samples against controls to assess changes in cartilage matrix composition at the molecular level.
Metabolic studies use radiolabeled tracer techniques and indirect calorimetry in animal models to track shifts in substrate utilization when AOD-9604 is introduced. Gene expression panels targeting lipolytic enzymes (HSL, ATGL) are also used to profile the peptide's molecular activity at the transcriptional level.
In lyophilized form, AOD-9604 research material should be stored at -20°C in a sealed container, protected from moisture and direct light. Under these conditions, the peptide maintains structural integrity for extended periods.
Once reconstituted for laboratory use, solutions should be kept at 4°C and used within 48 to 72 hours. Freeze-thaw cycles degrade the peptide and should be avoided; researchers typically prepare single-use aliquots prior to reconstitution.
AOD-9604 (HGH Fragment 176-191) for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $50. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
The current batch has a published third-party certificate of analysis, shown above. AOD-9604 is supplied as lyophilized powder, for laboratory and research use only, not for human consumption.
