Sema
Compounded in a licensed US 503A pharmacy 🇺🇸
GLP Research Peptide.
Sema is a GLP-1 receptor agonist analogue of human glucagon-like peptide-1, engineered with a C18 fatty diacid side chain for albumin binding and extended half-life, studied in metabolic and receptor pharmacology research. Preclinical researchers investigate its receptor binding kinetics at GLP-1R, downstream cAMP and insulin secretion pathways in pancreatic beta-cell models, and its effects on gastric emptying and appetite-regulatory circuits in laboratory settings. It is also examined in hepatic lipid metabolism studies and cardiovascular research models in preclinical contexts. Supplied as a precision-lyophilized peptide of analytical purity for controlled laboratory investigation only. Not for human or veterinary use.
- 30mg lyophilized format
- Research-grade formulation
- Precision measured
- Laboratory research only
Independently verified by Freedom Diagnostics via HPLC and mass spec. Every vial carries a unique accession number you can look up directly with the lab.
- 2-day shipping nationwide, flat $12.50
- Plain, discreet packaging. No product names on the outside.
- Tracking emailed the moment your order ships.
About Sema
Sema is a synthetic glucagon-like peptide-1 (GLP-1) receptor agonist engineered from the native 30-amino acid GLP-1(7-36) amide sequence, with strategic amino acid substitutions and a C18 fatty diacid chain attached at lysine-26 via a linker. These modifications extend its plasma half-life to approximately one week in vivo by facilitating albumin binding and reducing renal clearance, making it a compound of significant interest in metabolic and cardiovascular research.
GLP-1 receptor agonism has been studied extensively in the context of glucose-stimulated insulin secretion, glucagon suppression, gastric emptying modulation, and appetite-regulating circuits in the central nervous system. Sema, as a long-acting and highly selective GLP-1 receptor agonist, has been employed in both preclinical models and large-scale clinical research programs to characterize these pathways with temporal resolution not achievable with shorter-acting analogs.
Beyond pancreatic beta-cell and metabolic research, sema has been investigated in models of cardiovascular disease, kidney function, liver steatosis, and neurodegeneration. GLP-1 receptors are expressed in cardiac tissue, kidney tubules, hepatocytes, and neuronal populations, and sema has been used as a research tool to probe the physiological significance of GLP-1R signaling in these organ systems under controlled experimental conditions.
Buy Sema online
Sema (Semaglutide) is in stock and available to buy online from Optimum ReGen Peptides — a real American research-peptide company with a physical storefront in Medford, Oregon, not an anonymous overseas dropshipper. Priced from $125, every order ships within two business days, flat $12.50 nationwide, in plain discreet packaging with tracking.
As your Sema supplier we back every batch with a third-party certificate of analysis and compound in a licensed US 503A pharmacy. Vials are supplied lyophilized at analytical purity for laboratory and research use only, not for human consumption.
Researched For
Sema serves as a high-affinity, long-acting research tool for studying GLP-1 receptor activation kinetics, downstream signaling (cAMP, PKA, EPAC2), and receptor internalization/trafficking in pancreatic cell lines and heterologous expression systems.
Studies have investigated sema's effects on beta-cell insulin secretion dynamics, beta-cell mass preservation in diabetic models, and the transcriptional consequences of prolonged GLP-1R activation in isolated islets and INS-1 cell cultures.
GLP-1R is expressed in cardiomyocytes and coronary endothelium, and sema has been studied in cardiac ischemia-reperfusion models and inflammation paradigms to characterize cardioprotective signaling pathways at the molecular level.
Research has examined GLP-1R expression in hypothalamic nuclei and brainstem areas involved in energy balance. Studies use sema alongside GLP-1R-specific tracers and knockout models to map receptor-mediated anorectic signaling in the CNS.
Preclinical studies in diet-induced obesity models have investigated sema's effects on hepatic lipid accumulation, steatosis markers, and inflammatory cytokine expression in liver tissue, examining GLP-1R signaling as a modulator of hepatic lipid homeostasis.
How It Is Studied
Pharmacological characterization of sema at the GLP-1 receptor uses cAMP accumulation assays in GLP-1R-expressing HEK293 cells, radioligand competition binding with [125I]-GLP-1 or [3H]-exendin-4, and beta-arrestin recruitment BRET assays to determine binding affinity, efficacy, and biased agonism profiles. These in vitro studies establish the compound's receptor pharmacology independent of pharmacokinetic variables.
Beta-cell secretion studies use isolated pancreatic islets from rodent or human donors, exposing them to sema at defined concentrations during glucose-stimulated insulin secretion (GSIS) assays. Researchers measure insulin, C-peptide, and glucagon release by ELISA, and assess islet gene expression using RNA sequencing or targeted qPCR panels to characterize transcriptional responses to prolonged GLP-1R activation.
In vivo metabolic research employs diet-induced obesity mouse models (DIO C57BL/6) or genetic diabetic models (db/db, ob/ob) with controlled sema dosing and comprehensive metabolic phenotyping including indirect calorimetry, glucose and insulin tolerance tests, body composition by NMR or DXA, and tissue-level molecular profiling of liver, fat, and muscle samples.
Specifications
| Form | Lyophilized powder |
|---|---|
| Purity | >= 99% (HPLC) |
| Molecular Formula | C187H291N45O59 |
| Molar Mass | 4113.6 g/mol |
| CAS Number | 910463-68-2 |
Storage & Handling
Lyophilized sema research material should be stored at -20°C, protected from light and humidity. The fatty acid modification that enables albumin binding is stable under these conditions. Vials should be sealed with Parafilm or similar barrier material and equilibrated to room temperature under desiccant before opening.
Reconstituted sema solutions for in vitro use should be prepared in phosphate-buffered saline (pH 7.4) or similar physiological buffers and held at 4°C for up to one week given the compound's inherent stability. For in vivo studies, researchers prepare dosing solutions fresh and maintain cold-chain until administration. Glass vials are preferred over polypropylene to minimize peptide adsorption.
Frequently Asked Questions
How does sema's structure differ from native GLP-1 in research applications?+
What cell lines are commonly used for GLP-1R pharmacology research with sema?+
Has sema been studied in neurodegeneration research models?+
What large clinical research programs have investigated sema?+
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