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For laboratory research. Sold in 5mg, 10mg, 50mg kit and 100mg kit sizes.
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For research use only. Not for human consumption.
Tesamorelin is a 44-amino-acid synthetic peptide classified as a growth hormone-releasing hormone (GHRH) analogue. Structurally, it corresponds to the biologically active 1-44 fragment of human GHRH, with a trans-3-hexenoic acid group conjugated to the N-terminus. This modification is the defining feature that separates tesamorelin from native GHRH in laboratory characterization work, and it is the reason researchers select tesamorelin specifically when a longer plasma observation window is needed for pituitary-axis experiments.
As a GHRH analogue, tesamorelin is studied for its interaction with the GHRH receptor (GHRH-R) expressed on anterior pituitary somatotroph cells. Receptor binding activates a Gs-protein-coupled cascade that raises intracellular cAMP, a signaling step researchers track when characterizing growth hormone (GH) synthesis and pulsatile release in vitro and in animal models. Because tesamorelin retains full agonist activity at GHRH-R while resisting the enzymatic cleavage that limits native GHRH, it has become a standard reference compound in GHRH analogue research on receptor selectivity, signal transduction, and comparative pharmacokinetics.
The trans-3-hexenoic acid modification protects tesamorelin from dipeptidyl peptidase IV (DPP-IV), the enzyme primarily responsible for the rapid plasma clearance of unmodified GHRH. Plasma incubation studies paired with LC-MS/MS quantification are the standard methodology researchers use to characterize this resistance, comparing degradation curves of tesamorelin against native GHRH and against other GHRH-axis analogues such as sermorelin and CJC-1295. This comparative stability profile is a recurring reference point in peptide-axis literature and a key reason tesamorelin research peptide protocols favor it for extended time-course sampling.
Beyond receptor pharmacology, tesamorelin research peptide protocols extend into GH/IGF-1 axis regulation, visceral adipose tissue biology, hepatic lipid metabolism, and, in more exploratory work, hippocampal and cognitive-marker studies. Rodent and in vitro models are used to examine how sustained GHRH receptor stimulation feeds forward into IGF-1 production, adipocyte gene expression, and lipoprotein profiles.
For laboratory preparation, consult the product documentation and validate the diluent, working concentration, storage conditions, and use period for the intended assay. A formulation containing a preservative and one without it may require different handling; a generic protocol does not establish stability for this product.
Optimum ReGen Peptides is a research-use retailer offering tesamorelin in multiple product options. Review current quantities, product specifications, available batch reports, and handling guidance before ordering. Contact us for documentation on the specific product and lot. These research materials are not intended for human or animal use.
This tesamorelin listing is intended strictly for laboratory and in vitro research by qualified professionals and institutions. It is not for human consumption, not for veterinary use, and is not intended to diagnose, treat, cure, or prevent any disease. No content on this page constitutes medical advice or guidance for human administration; all handling described here refers to laboratory research protocol only.
The areas where this compound appears in the published research literature.
In preclinical rodent studies, blood is sampled at defined intervals to construct GH pulse profiles using ultrasensitive immunoassays. IGF-1 and IGFBP-3 serum levels are quantified by ELISA as downstream markers of somatotroph axis stimulation. Adipose tissue is harvested for gene expression profiling using RT-PCR panels targeting lipogenic and lipolytic enzyme genes.
Researchers characterize Tesamorelin's DPP-IV resistance by incubating the compound in plasma preparations and comparing intact peptide recovery over time against unmodified GHRH using LC-MS/MS. This confirms that the N-terminal modification confers the intended enzymatic stability and validates the pharmacokinetic rationale for the structural design.
In metabolic research designs, indirect calorimetry, body composition analysis by DEXA or MRI, and comprehensive metabolic panel measurement are used as systemic endpoint readouts in animal model studies. Researchers also examine pituitary somatotroph density and GH granule content by electron microscopy in long-term treatment cohorts to assess gland-level response to chronic GHRH receptor stimulation.
Lyophilized Tesamorelin should be stored at -20 °C, protected from light and humidity, in sealed vials. The lyophilized form is stable for extended periods under these conditions. For reconstitution, sterile water or the provided diluent is used; the reconstituted solution should be used promptly, ideally within 24 hours when no preservative is present, or within the timeframe specified by the study protocol.
Tesamorelin solutions should not be vigorously shaken, as mechanical agitation can disrupt protein structure. Gentle swirling is the recommended mixing method. Any unused reconstituted solution should be discarded at the end of the working day. Pre-aliquoting the lyophilized powder into single-experiment portions before any reconstitution minimizes waste and cycle-related degradation.
Tesamorelin for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $60. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
The current batch has a published third-party certificate of analysis, shown above. Tesamorelin is supplied as lyophilized powder, for laboratory and research use only, not for human consumption.
