All research products on this site, including all peptides, are sold strictly for laboratory and research use only, not for human or animal consumption, diagnostic, or therapeutic use. Our tallow skincare products are topical cosmetics. You must be 21 or older to enter.
By entering you confirm you are 21+ and accept these products are for research use only. See our Terms and Disclaimer.
For laboratory research. Sold in 10mg and 100mg sizes.
Complete the order
Supplies and compounds researchers add to this order
Identity, purity and handling data for this compound, in one place. Tap an identifier to copy it.
For research use only. Not for human consumption.
SS-31 is the common research designation for Elamipretide, also documented in the peptide science literature as Szeto-Schiller peptide 31, Bendavia, or MTP-131. Structurally it is a small aromatic-cationic tetrapeptide, D-Arg-Dmt-Lys-Phe-NH2, built from alternating positively charged and aromatic residues. That alternating sequence is the design feature researchers point to when explaining why SS-31 behaves differently from most peptides studied in cell biology: instead of acting at a surface receptor, it partitions directly into the inner mitochondrial membrane, which is the structural basis for calling it a mitochondrial-targeted peptide.
In laboratory research, SS-31 is studied primarily for its interaction with cardiolipin, a phospholipid found almost exclusively in the inner mitochondrial membrane and required for organizing the electron transport chain into functional supercomplexes. Investigators use SS-31 as a chemical probe to ask what changes when cardiolipin architecture is preserved under stress, tracking readouts such as membrane potential, cristae morphology by electron microscopy, and electron transport chain complex activity in isolated mitochondria and cultured cell models.
The Szeto-Schiller peptide series, named for the chemists who first characterized this class of aromatic-cationic peptides, was developed specifically to concentrate in mitochondria without relying on a delivery vehicle or targeting sequence. SS-31 is the most widely cited compound from that series in the published research record, and it is frequently referenced alongside related probes when researchers are mapping structure-activity relationships for mitochondrial-membrane-directed peptides.
A large share of the preclinical literature on SS-31, referred to as Elamipretide in that body of work, concerns oxidative stress and bioenergetic dysfunction models: ischemia-reperfusion protocols in isolated heart and kidney tissue, aged-cell and senescence models, and genetic cardiolipin-deficiency models such as Barth syndrome cell lines. Researchers in these settings typically quantify reactive oxygen species output with probes like MitoSOX or DCF-DA, and pair that with ATP production assays and oxygen consumption measurements to characterize mitochondrial respiratory function.
Because SS-31 and Elamipretide describe the same molecule, literature search strategies for this compound need to track both terms, along with Szeto-Schiller peptide 31 and MTP-131, to capture the full relevant dataset. This naming overlap is a frequent point of confusion for researchers building a bibliography, since older biochemistry papers tend to use the Szeto-Schiller or SS-31 designation while later publications adopt the Elamipretide name.
Optimum ReGen Peptides offers SS-31 for laboratory research. Review the available specifications, batch reports, and handling guidance before ordering. These research materials are not intended for human or animal use.
The areas where this compound appears in the published research literature.
In laboratory research, SS-31 is applied to isolated mitochondria preparations, cell cultures, or living cells to examine its effects on mitochondrial membrane potential (assessed by JC-1 or TMRE fluorescence), oxygen consumption rate (measured by Seahorse XF analysis), and ROS generation (measured by MitoSOX or analogous fluorescent probes).
Preclinical in vivo studies administer SS-31 to rodents before or after ischemic insults, measuring cardiac function by echocardiography and pressure-volume loop analysis, renal function by creatinine and BUN levels, and tissue histology to assess the extent of injury and any protective effects associated with treatment.
Biochemical studies use blue native PAGE and electron microscopy to examine ETC complex superassembly and cristae ultrastructure in mitochondria treated with SS-31, providing structural correlates for observed functional improvements in bioenergetics assays. Cardiolipin content and acyl chain composition are measured by mass spectrometry to characterize the lipid environment of the IMM.
Lyophilized SS-31 should be stored at -20 °C in a sealed, desiccated vial protected from direct light. The lyophilized peptide is stable under these conditions for extended periods. For cell-based research, SS-31 is commonly reconstituted in sterile water, PBS, or DMSO (for hydrophobic assay contexts) to prepare stock solutions.
Reconstituted SS-31 solutions should be aliquoted into single-experiment volumes and stored at -80 °C if not used immediately. Avoid repeated freeze-thaw cycles, which can lead to peptide aggregation and loss of activity. Verify peptide integrity by HPLC for long-running research programs where stock stability is a concern.
SS-31 (Elamipretide) for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $60. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
The current batch has a published third-party certificate of analysis, shown above. SS-31 is supplied as lyophilized powder, for laboratory and research use only, not for human consumption.
