0105 areas
Estrogen-related receptor (ERR) pharmacology
SLU-PP-332 is used as a selective ERRa/b/g pan-agonist tool compound in transcription reporter assays and co-activator interaction studies to probe ERR-dependent gene regulatory mechanisms.
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SLU‑PP-332
For laboratory research. Sold in 1mg tabs and 500mcg tabs sizes.
$110.40
$16031% off
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Lab sheet
SLU-PP-332 details
Identity, purity and handling data for this compound, in one place. Tap an identifier to copy it.
Certificate of analysis
Not published yet
A third-party certificate for SLU-PP-332 is not published here yet. If your work needs one, ask us before ordering and we will tell you what testing is available for the current lot.
Ask about a certificateMolar Mass
395.46 g/mol
CAS Number
2416928-77-1
Form
Tablets
Full data sheet+
- Purity
- See the available batch report for the tested sample's purity. Confirm the product and lot before ordering.
For research use only. Not for human consumption.
Overview
About SLU-PP-332
SLU-PP-332 is a synthetic small-molecule agonist of estrogen-related receptors (ERRs), specifically developed as a selective activator of ERR-alpha (ERRa), ERR-beta (ERRb), and ERR-gamma (ERRg). These orphan nuclear receptors are key transcriptional regulators of mitochondrial biogenesis, oxidative phosphorylation, and fatty acid oxidation gene programs. SLU-PP-332 was developed at Saint Louis University as a chemical probe to investigate ERR-dependent metabolic transcription in cell and animal models.
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Research interest in SLU-PP-332 centers on its ability to transcriptionally activate programs resembling endurance exercise-induced adaptations. In preclinical studies, administration of SLU-PP-332 has been associated with increased expression of PGC-1 target genes, enhanced mitochondrial density markers, and changes in metabolic substrate utilization in muscle tissue models.
SLU-PP-332 is provided as a research compound for laboratory investigation of ERR biology, mitochondrial metabolism, and exercise mimetic pharmacology. It is not approved for human or veterinary use and must be used only in compliant laboratory research settings.
Research context
What SLU-PP-332 is researched for
The areas where this compound appears in the published research literature.
Methodology
How SLU-PP-332 is studied
01Method 1In cell culture experiments, SLU-PP-332 is typically dissolved in DMSO and diluted to micromolar working concentrations in cell medium.+
In cell culture experiments, SLU-PP-332 is typically dissolved in DMSO and diluted to micromolar working concentrations in cell medium. Researchers treat myoblast or cardiac cell lines and measure outcomes including mRNA expression of ERR target genes (ESRRA, VEGFA, PDK4, ACADM), oxygen consumption rate via Seahorse XF analysis, and protein-level markers of mitochondrial content.
02Method 2In vivo rodent studies collect tissue for transcriptomic analysis.+
In vivo rodent studies collect tissue for transcriptomic analysis. Researchers compare treated and vehicle cohorts on measures of skeletal muscle gene expression, treadmill performance endpoints, and metabolic parameters under defined dietary conditions.
03Method 3Structural and biochemical studies use ERR ligand binding domain preparations to characterize SLU-PP-332's binding mode, coactivator peptide displacement, and…+
Structural and biochemical studies use ERR ligand binding domain preparations to characterize SLU-PP-332's binding mode, coactivator peptide displacement, and receptor stabilization using thermal shift assays and X-ray crystallography, providing mechanistic grounding for the cellular observations.
Storage protocols
SLU-PP-332 storage and handling
Full handling protocol+
This listing supplies SLU-PP-332 tablets. Follow the packaging and supplier handling instructions for this formulation. Storage and solvent information for a pure laboratory powder does not establish the preparation or stability of a finished tablet.
Obtain formulation and lot documentation before laboratory work, and validate sample preparation and storage conditions for the intended assay.
Ordering & shipping
Buy SLU-PP-332 online
SLU-PP-332 for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $125. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
SLU-PP-332 is supplied as tablets, for laboratory and research use only, not for human consumption.
FAQ
SLU-PP-332 FAQ
Which ERR subtypes does SLU-PP-332 activate?
SLU-PP-332 is a pan-ERR agonist with reported activity at ERRa (encoded by ESRRA), ERRb (ESRRB), and ERRg (ESRRG). Researchers use it to study shared ERR transcriptional programs, or combine it with subtype-selective antagonists to dissect individual receptor contributions.
How does SLU-PP-332 relate to exercise biology research?
ERRa and ERRg are among the transcriptional mediators of mitochondrial gene programs induced by endurance exercise. SLU-PP-332 activates these receptors pharmacologically, making it a tool for studying the transcriptional machinery of exercise adaptation independently of physical exertion in cell and animal models.
What solvent is used to dissolve SLU-PP-332?
SLU-PP-332 is a small molecule that dissolves in DMSO. Stock solutions in DMSO are typically prepared at 10-50 mM and diluted in aqueous media for cell experiments. Final DMSO concentration in assay media should be kept below 0.1% to avoid cytotoxicity artifacts.
Is SLU-PP-332 a peptide or a small molecule?
SLU-PP-332 is a synthetic small molecule, not a peptide. It acts as a nuclear receptor agonist that binds directly to the ligand binding domain of ERR proteins, rather than activating a cell-surface receptor like most research peptides.
What is the published research background on SLU-PP-332?
SLU-PP-332 was first described in research from Saint Louis University published in the Journal of Medicinal Chemistry. Subsequent studies at institutions including the Salk Institute have used it to investigate ERR-dependent exercise and metabolic gene programs in animal models.
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