SLU-PP-332
Compounded in a licensed US 503A pharmacy 🇺🇸
Research Compound Tablets.
SLU-PP-332 is a small-molecule agonist of the estrogen-related receptor alpha (ERRalpha), researched as a tool compound in mitochondrial biogenesis and exercise-mimetic biology studies. Laboratory investigators study its effects on PGC-1alpha co-activation, mitochondrial oxidative phosphorylation gene programs, and fatty acid beta-oxidation in skeletal muscle cell models. It is also examined in metabolic endurance models in preclinical research to understand ERR nuclear receptor biology at a mechanistic level. Supplied in precision-measured tablet format for controlled laboratory investigation only. For research use only; not intended for human consumption.
- 500mcg tablet format
- Precision-measured dosing
- Research-grade compound
- Laboratory research only
Independently verified by Freedom Diagnostics via HPLC and mass spec. Every vial carries a unique accession number you can look up directly with the lab.
- 2-day shipping nationwide, flat $12.50
- Plain, discreet packaging. No product names on the outside.
- Tracking emailed the moment your order ships.
About SLU-PP-332
SLU-PP-332 is a synthetic small-molecule agonist of estrogen-related receptors (ERRs), specifically developed as a selective activator of ERR-alpha (ERRa), ERR-beta (ERRb), and ERR-gamma (ERRg). These orphan nuclear receptors are key transcriptional regulators of mitochondrial biogenesis, oxidative phosphorylation, and fatty acid oxidation gene programs. SLU-PP-332 was developed at Saint Louis University as a chemical probe to investigate ERR-dependent metabolic transcription in cell and animal models.
Research interest in SLU-PP-332 centers on its ability to transcriptionally activate programs resembling endurance exercise-induced adaptations. In preclinical studies, administration of SLU-PP-332 has been associated with increased expression of PGC-1 target genes, enhanced mitochondrial density markers, and changes in metabolic substrate utilization in muscle tissue models.
SLU-PP-332 is provided as a research compound for laboratory investigation of ERR biology, mitochondrial metabolism, and exercise mimetic pharmacology. It is not approved for human or veterinary use and must be used only in compliant laboratory research settings.
Buy SLU-PP-332 online
SLU-PP-332 is in stock and available to buy online from Optimum ReGen Peptides — a real American research-peptide company with a physical storefront in Medford, Oregon, not an anonymous overseas dropshipper. Priced from $125, every order ships within two business days, flat $12.50 nationwide, in plain discreet packaging with tracking.
As your SLU-PP-332 supplier we back every batch with a third-party certificate of analysis and compound in a licensed US 503A pharmacy. Vials are supplied lyophilized at analytical purity for laboratory and research use only, not for human consumption.
Researched For
SLU-PP-332 is used as a selective ERRa/b/g pan-agonist tool compound in transcription reporter assays and co-activator interaction studies to probe ERR-dependent gene regulatory mechanisms.
Cell-based studies have examined how SLU-PP-332 treatment influences markers of mitochondrial biogenesis including PGC-1 alpha coactivation, citrate synthase activity, and mtDNA copy number in skeletal muscle cell lines.
ERRs regulate transcription of fatty acid oxidation enzymes. SLU-PP-332 is used to investigate how ERR activation shifts cellular fuel utilization from glucose toward lipid oxidation in metabolic cell models.
Preclinical rodent studies have investigated whether SLU-PP-332 reproduces gene expression signatures of endurance exercise training in muscle tissue, providing a model for studying exercise-related metabolic adaptations pharmacologically.
Research has explored SLU-PP-332's effects in models of heart failure and metabolic dysfunction, where ERR-regulated mitochondrial programs are known to be dysregulated.
How It Is Studied
In cell culture experiments, SLU-PP-332 is typically dissolved in DMSO and diluted to micromolar working concentrations in cell medium. Researchers treat myoblast or cardiac cell lines and measure outcomes including mRNA expression of ERR target genes (ESRRA, VEGFA, PDK4, ACADM), oxygen consumption rate via Seahorse XF analysis, and protein-level markers of mitochondrial content.
In vivo rodent studies have administered SLU-PP-332 by intraperitoneal injection, with tissue collection for transcriptomic analysis. Researchers compare treated and vehicle cohorts on measures of skeletal muscle gene expression, treadmill performance endpoints, and metabolic parameters under defined dietary conditions.
Structural and biochemical studies use ERR ligand binding domain preparations to characterize SLU-PP-332's binding mode, coactivator peptide displacement, and receptor stabilization using thermal shift assays and X-ray crystallography, providing mechanistic grounding for the cellular observations.
Specifications
| Form | Lyophilized powder |
|---|---|
| Purity | >= 99% (HPLC) |
| CAS Number | 2416928-77-1 |
| Molar Mass | 395.46 g/mol |
Storage & Handling
Store lyophilized SLU-PP-332 at -20 C, protected from moisture and light. For working solutions, dissolve in DMSO to prepare a stock, then dilute in aqueous buffer or cell culture medium immediately before use. DMSO stock solutions at -20 C are stable for several months. Avoid repeated freeze-thaw of stock solutions. Because SLU-PP-332 is a small molecule rather than a peptide, standard organic compound handling precautions apply. Document lot, preparation date, and storage conditions in laboratory records.
Frequently Asked Questions
Which ERR subtypes does SLU-PP-332 activate?+
How does SLU-PP-332 relate to exercise biology research?+
What solvent is used to dissolve SLU-PP-332?+
Is SLU-PP-332 a peptide or a small molecule?+
What is the published research background on SLU-PP-332?+
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