PT-141
Compounded in a licensed US 503A pharmacy 🇺🇸
Receptor Pathway Research Peptide.
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide derived from Melanotan II, studied in melanocortin receptor pharmacology with a focus on MC4R and MC3R activation in laboratory and preclinical models. Researchers investigate its central nervous system receptor signaling profiles and its pharmacokinetic properties compared to its linear parent compound using in vitro receptor binding assays. It serves as a reference compound in studies of the melanocortin receptor family and hypothalamic neuropeptide signaling circuits. Supplied as a lyophilized peptide of 10mg at high analytical purity for in vitro and preclinical research use only. Store at -20 degrees C.
- 10mg format
- Precision lyophilized powder
- Laboratory research only
Independently verified by Freedom Diagnostics via HPLC and mass spec. Every vial carries a unique accession number you can look up directly with the lab.
- 2-day shipping nationwide, flat $12.50
- Plain, discreet packaging. No product names on the outside.
- Tracking emailed the moment your order ships.
About PT-141
PT-141, known in the pharmaceutical literature as bremelanotide, is a cyclic heptapeptide melanocortin receptor agonist. It is a structural derivative of Melanotan II, generated through hydrolysis of the C-terminal amide, and retains agonist activity at MC1R, MC3R, and MC4R subtypes. Research interest in PT-141 has focused particularly on its activity at central MC4R populations involved in neuroendocrine and autonomic signaling.
PT-141 has been investigated in preclinical and clinical research contexts, including studies examining MC4R-mediated autonomic pathways. It was the subject of clinical development for hypoactive sexual desire disorder (HSDD) and received FDA approval as Vyleesi for this indication in 2019, making bremelanotide one of the few melanocortin compounds with a defined clinical data package.
As a research compound, PT-141 is used in laboratory settings to probe melanocortin receptor biology, particularly in models focused on MC4R signaling. It is provided here for research use only and not for human or veterinary therapeutic application outside of formally regulated clinical contexts.
Buy PT-141 online
PT-141 (Bremelanotide) is in stock and available to buy online from Optimum ReGen Peptides — a real American research-peptide company with a physical storefront in Medford, Oregon, not an anonymous overseas dropshipper. Priced from $50, every order ships within two business days, flat $12.50 nationwide, in plain discreet packaging with tracking.
As your PT-141 supplier we back every batch with a third-party certificate of analysis and compound in a licensed US 503A pharmacy. Vials are supplied lyophilized at analytical purity for laboratory and research use only, not for human consumption.
Researched For
PT-141 is studied in hypothalamic cell models and animal studies to investigate MC4R-mediated intracellular signaling cascades, receptor trafficking, and crosstalk with other neuroendocrine pathways.
Preclinical studies have used PT-141 to probe the contribution of central MC4R activation to autonomic outflow affecting peripheral vascular and erectile tissue in rodent models.
Researchers have employed PT-141 to study how MC3R and MC4R agonism interacts with POMC neuron populations in the arcuate nucleus and other brain regions involved in neuroendocrine regulation.
Studies have compared PT-141 and MT-2 side-by-side in receptor binding, functional, and in vivo assays to characterize the pharmacological consequences of the terminal amide modification.
Some research has examined effects of melanocortin receptor activation on vascular smooth muscle and endothelial cell signaling using PT-141 as a pharmacological tool in cell culture models.
How It Is Studied
In vitro studies employ PT-141 in MC receptor-transfected cell lines (commonly HEK293 or CHO cells) to generate binding affinity data and cAMP concentration-response profiles across MC1R, MC3R, MC4R, and MC5R. These assays establish the potency and selectivity characteristics that guide interpretation of in vivo studies.
Animal studies investigating autonomic physiology have used intracerebroventricular or intraperitoneal PT-141 administration in combination with receptor antagonists to pharmacologically dissect the receptor populations responsible for observed physiological responses.
Pharmacokinetic studies have characterized the metabolite profile and plasma half-life of PT-141 relative to MT-2, providing data on the structural features that influence receptor engagement duration in laboratory model systems.
Specifications
| Form | Lyophilized powder |
|---|---|
| Purity | >= 99% (HPLC) |
| Molecular Formula | C50H68N14O10 |
| CAS Number | 189691-06-3 |
| Sequence | Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Molar Mass | 1025.17 g/mol |
Storage & Handling
Store lyophilized PT-141 at -20 C or below, protected from moisture and light. In the lyophilized state, the compound is stable for extended periods. Once reconstituted in bacteriostatic water or sterile saline, store at 4 C and use within the validated stability window. For longer retention, aliquot into single-use volumes and store at -80 C to minimize freeze-thaw degradation. Document reconstitution dates, lot numbers, and storage conditions in accordance with laboratory quality requirements.
Frequently Asked Questions
What is the structural relationship between PT-141 and MT-2?+
What melanocortin receptors does PT-141 engage?+
Is bremelanotide (PT-141) an approved pharmaceutical?+
How is PT-141 different from flibanserin?+
What concentration range is used in PT-141 receptor studies?+
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