MT-2
Compounded in a licensed US 503A pharmacy 🇺🇸
Melanocortin Research Peptide.
MT-2 (Melanotan II) is a synthetic cyclic heptapeptide analogue of alpha-MSH studied in melanocortin receptor (MC1R, MC3R, MC4R) pharmacology and pigmentation research models. Laboratory investigators examine its receptor binding affinities across the melanocortin receptor family and downstream cAMP signaling cascades in cell culture systems. It is also employed in preclinical neuroscience research studying MC4R-mediated signaling in hypothalamic neural circuits. Supplied as a lyophilized peptide of 10mg at high analytical purity for in vitro and preclinical research use only. Store at -20 degrees C and reconstitute under aseptic conditions.
- 10mg vial
- High purity
- Research use only
Independently verified by Freedom Diagnostics via HPLC and mass spec. Every vial carries a unique accession number you can look up directly with the lab.
- 2-day shipping nationwide, flat $12.50
- Plain, discreet packaging. No product names on the outside.
- Tracking emailed the moment your order ships.
About MT-2
MT-2 (Melanotan II) is a synthetic analogue of alpha-melanocyte-stimulating hormone (alpha-MSH), a naturally occurring neuropeptide derived from the proopiomelanocortin (POMC) precursor. It acts as a non-selective agonist at melanocortin receptors (MC1R through MC5R), with particular research interest focused on its activity at MC1R, MC3R, and MC4R subtypes.
The melanocortin system is involved in a diverse range of physiological processes studied in the laboratory, including pigmentation pathways, energy homeostasis, immune modulation, and reproductive biology. MT-2 has been widely used as a pharmacological probe to dissect the contributions of individual melanocortin receptor subtypes to these systems in preclinical research.
MT-2 is a research compound intended exclusively for laboratory investigation. It is not approved for human or veterinary therapeutic use, and all research involving this peptide must be conducted under appropriate institutional oversight and in compliance with applicable regulations.
Buy MT-2 online
MT-2 (Melanotan II) is in stock and available to buy online from Optimum ReGen Peptides — a real American research-peptide company with a physical storefront in Medford, Oregon, not an anonymous overseas dropshipper. Priced from $50, every order ships within two business days, flat $12.50 nationwide, in plain discreet packaging with tracking.
As your MT-2 supplier we back every batch with a third-party certificate of analysis and compound in a licensed US 503A pharmacy. Vials are supplied lyophilized at analytical purity for laboratory and research use only, not for human consumption.
Researched For
MT-2 is employed as a reference agonist in melanocortin receptor binding and functional assays, enabling researchers to characterize receptor subtypes and investigate downstream signaling in cell-based models.
MC1R agonism by MT-2 has been studied in melanocyte cell cultures to investigate eumelanin synthesis pathways, cAMP signaling, and tyrosinase activity relevant to pigmentation biology.
MC4R is expressed in hypothalamic neurons involved in appetite and energy expenditure regulation. MT-2 has been used in rodent models to probe how melanocortin receptor activation influences feeding behavior and metabolic parameters.
Preclinical studies have investigated MT-2's central and peripheral effects on autonomic neural pathways associated with penile erection in animal models, contributing to understanding of MC4R roles in reproductive physiology.
MC3R and MC1R are expressed on immune cells. Laboratory research has examined how melanocortin agonists including MT-2 influence cytokine production and inflammatory signaling in macrophage and T-cell models.
How It Is Studied
In cell culture systems, MT-2 is applied to receptor-expressing cell lines at defined concentrations to generate concentration-response curves for cAMP accumulation and receptor internalization, providing data on potency and efficacy at each MC receptor subtype.
In vivo rodent studies have been used to investigate the behavioral and physiological effects of MC receptor activation. Central administration (intracerebroventricular) and peripheral administration designs allow researchers to distinguish central from peripheral contributions to observed outcomes.
Competitive binding assays using radiolabeled or fluorescent ligands characterize MT-2's affinity across the five MC receptor subtypes, providing selectivity data that guides interpretation of in vivo findings and comparison to more selective tool compounds.
Specifications
| Form | Lyophilized powder |
|---|---|
| Purity | >= 99% (HPLC) |
| Molecular Formula | C50H69N15O9 |
| CAS Number | 121062-08-6 |
| Sequence | Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 |
| Molar Mass | 1024.18 g/mol |
Storage & Handling
Store lyophilized MT-2 at -20 C or below, protected from light and moisture. The lyophilized form is stable for extended periods under these conditions. Reconstitute in bacteriostatic water or sterile saline using standard aseptic technique. Store reconstituted solutions at 4 C for short-term use or aliquot and freeze at -80 C. Minimize freeze-thaw cycles to preserve peptide integrity. All storage and handling should adhere to institutional biosafety and chemical hygiene protocols.
Frequently Asked Questions
What is the receptor selectivity profile of MT-2?+
How does MT-2 differ from alpha-MSH structurally?+
What cell models are commonly used in MT-2 receptor studies?+
Is MT-2 the same as Melanotan 1 (MT-1)?+
What is the difference between MT-2 and PT-141 (bremelanotide)?+
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