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MT-1

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Melanocortin Research Peptide.

$50
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MT-1 (Melanotan-I, afamelanotide) is a synthetic linear analogue of alpha-MSH — [Nle4, D-Phe7]-alpha-MSH — studied in melanocortin receptor pharmacology with a preference for the MC1R subtype. Laboratory investigators use it alongside the cyclic analogue MT-2 as a complementary tool compound when separating MC1R-driven effects from broader melanocortin receptor activity in cell culture and preclinical models. Supplied as a lyophilized peptide of 10mg at high analytical purity for in vitro and preclinical research use only. Store at -20 degrees C and reconstitute under aseptic conditions.

Why you'll like it
  • 10mg vial
  • High purity
  • Research use only
≥99%
HPLC purity
Certificate of analysis
Third-party tested. Every batch.

Independently verified by Freedom Diagnostics via HPLC and mass spec. Every vial carries a unique accession number you can look up directly with the lab.

Verify COA · Freedom Diagnostics
In every order
Peptide vial(s)
Alcohol prep pads
Storage guide
Shipping & returns
  • 2-day shipping nationwide, flat $12.50
  • Plain, discreet packaging. No product names on the outside.
  • Tracking emailed the moment your order ships.
Overview

About MT-1

MT-1 (Melanotan-I, also referred to as afamelanotide) is a synthetic linear analogue of alpha-melanocyte-stimulating hormone (alpha-MSH), a neuropeptide derived from the proopiomelanocortin (POMC) precursor. Structurally it is [Nle4, D-Phe7]-alpha-MSH: the native sequence with a norleucine substitution at position 4 and a D-phenylalanine at position 7, modifications that increase metabolic stability and receptor binding affinity relative to native alpha-MSH.

Unlike the cyclic analogue MT-2, MT-1 retains the linear 13-residue backbone of alpha-MSH and shows a preference for the MC1R subtype. That selectivity profile is why laboratory investigators use the two as complementary tool compounds when dissecting which melanocortin receptor subtype drives an observed effect in a given model system.

MT-1 is a research compound intended exclusively for laboratory investigation. It is not approved for human or veterinary therapeutic use, and all research involving this peptide must be conducted under appropriate institutional oversight.

Ordering & shipping

Buy MT-1 online

MT-1 is in stock and available to buy online from Optimum ReGen Peptides — a real American research-peptide company with a physical storefront in Medford, Oregon, not an anonymous overseas dropshipper. Priced from $50, every order ships within two business days, flat $12.50 nationwide, in plain discreet packaging with tracking.

As your MT-1 supplier we back every batch with a third-party certificate of analysis and compound in a licensed US 503A pharmacy. Vials are supplied lyophilized at analytical purity for laboratory and research use only, not for human consumption.

Storage protocols

Storage & Handling

Store lyophilized MT-1 at -20 C or below, protected from light and moisture. The lyophilized form is stable for extended periods under these conditions. Reconstitute in bacteriostatic water or sterile saline using standard aseptic technique. Store reconstituted solutions at 4 C for short-term use, or aliquot and freeze at -80 C. Minimize freeze-thaw cycles to preserve peptide integrity. All storage and handling should adhere to institutional biosafety and chemical hygiene protocols.

FAQ

Frequently Asked Questions

How does MT-1 differ from MT-2?+
MT-1 (Melanotan-I) is a linear 13-residue alpha-MSH analogue with a preference for MC1R. MT-2 (Melanotan II) is a cyclic heptapeptide with broader, non-selective activity across MC1R through MC5R. They are distinct molecules with different molecular weights (approximately 1647 Da and 1024 Da respectively) and are used as complementary tool compounds in receptor studies.
What structural modifications distinguish MT-1 from native alpha-MSH?+
MT-1 is [Nle4, D-Phe7]-alpha-MSH — a norleucine substitution at position 4 and a D-phenylalanine at position 7. Both substitutions increase resistance to enzymatic degradation and raise receptor binding affinity relative to the native linear peptide.
What receptor subtype does MT-1 primarily engage in research models?+
Published work characterizes MT-1 as preferring MC1R among the melanocortin receptor family, which is the basis for its use in pigmentation pathway research as distinct from MC3R/MC4R-focused investigations.
What cell models are commonly used in MT-1 receptor studies?+
HEK293 cells transfected with individual melanocortin receptor subtypes are standard for binding and cAMP assays. Melanocyte lines such as B16-F10 and primary human melanocytes are used for pigmentation pathway work.
How is MT-1 purity verified for research-grade material?+
Purity is verified by HPLC with UV detection and molecular identity confirmed by mass spectrometry. The Certificate of Analysis for this batch reports 99.90% purity with identity confirmed as Melanotan-I.
Is MT-1 approved for clinical or veterinary use?+
No. MT-1 is supplied exclusively as a laboratory research compound and is not approved for clinical, veterinary, or any other non-research use.
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Research library

MT-1 research guides