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MT‑1

For laboratory research use only.

$42.50
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Lab sheet

MT-1, measured

Identity, purity and handling data for this compound, in one place. Tap an identifier to copy it.

Certificate of analysis
99.90%
HPLC purity, 10mg lot, reported 07/20/2026
Tested by Freedom Diagnostics, an independent lab. Search code Opti2607170029
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For research use only. Not for human consumption.

Overview

About MT-1

MT-1 (Melanotan-I, also referred to as afamelanotide) is a synthetic linear analogue of alpha-melanocyte-stimulating hormone (alpha-MSH), a neuropeptide derived from the proopiomelanocortin (POMC) precursor. Structurally it is [Nle4, D-Phe7]-alpha-MSH: the native sequence with a norleucine substitution at position 4 and a D-phenylalanine at position 7, modifications that increase metabolic stability and receptor binding affinity relative to native alpha-MSH.

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Unlike the cyclic analogue MT-2, MT-1 retains the linear 13-residue backbone of alpha-MSH and shows a preference for the MC1R subtype. That selectivity profile is why laboratory investigators use the two as complementary tool compounds when dissecting which melanocortin receptor subtype drives an observed effect in a given model system.

MT-1 is a research compound intended exclusively for laboratory investigation. It is not approved for human or veterinary therapeutic use, and all research involving this peptide must be conducted under appropriate institutional oversight.

Storage protocols

MT-1 storage and handling

Full handling protocol+

Store lyophilized MT-1 at -20 C or below, protected from light and moisture. The lyophilized form is stable for extended periods under these conditions. Reconstitute in bacteriostatic water or sterile saline using standard aseptic technique. Store reconstituted solutions at 4 C for short-term use, or aliquot and freeze at -80 C. Minimize freeze-thaw cycles to preserve peptide integrity. All storage and handling should adhere to institutional biosafety and chemical hygiene protocols.

Ordering & shipping

Buy MT-1 online

MT-1 for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $50. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.

The current batch has a published third-party certificate of analysis, shown above. MT-1 is supplied for laboratory and research use only, not for human consumption.

FAQ

MT-1 FAQ

How does MT-1 differ from MT-2?
MT-1 (Melanotan-I) is a linear 13-residue alpha-MSH analogue with a preference for MC1R. MT-2 (Melanotan II) is a cyclic heptapeptide with broader, non-selective activity across MC1R through MC5R. They are distinct molecules with different molecular weights (approximately 1647 Da and 1024 Da respectively) and are used as complementary tool compounds in receptor studies.
What structural modifications distinguish MT-1 from native alpha-MSH?
MT-1 is [Nle4, D-Phe7]-alpha-MSH — a norleucine substitution at position 4 and a D-phenylalanine at position 7. Both substitutions increase resistance to enzymatic degradation and raise receptor binding affinity relative to the native linear peptide.
What receptor subtype does MT-1 primarily engage in research models?
Published work characterizes MT-1 as preferring MC1R among the melanocortin receptor family, which is the basis for its use in pigmentation pathway research as distinct from MC3R/MC4R-focused investigations.
What cell models are commonly used in MT-1 receptor studies?
HEK293 cells transfected with individual melanocortin receptor subtypes are standard for binding and cAMP assays. Melanocyte lines such as B16-F10 and primary human melanocytes are used for pigmentation pathway work.
How is MT-1 purity verified for research-grade material?
Purity is verified by HPLC with UV detection and molecular identity confirmed by mass spectrometry. The Certificate of Analysis for this batch reports 99.90% purity with identity confirmed as Melanotan-I.
Is MT-1 approved for clinical or veterinary use?
No. MT-1 is supplied exclusively as a laboratory research compound and is not approved for clinical, veterinary, or any other non-research use.
Research library

MT-1 research guides

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