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For laboratory research. Sold in 10mg and 100mg kit sizes.
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For research use only. Not for human consumption.
KPV is a tripeptide derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (alpha-MSH), composed of the amino acids lysine, proline, and valine. As a fragment of alpha-MSH, KPV has been studied in laboratory settings for its potential to engage melanocortin receptor pathways, which are involved in the regulation of inflammatory signaling cascades.
Research has investigated KPV in the context of intestinal inflammation, wound biology, and innate immune modulation. Studies in cell culture and preclinical animal models have examined how this small peptide interacts with melanocortin receptors expressed on immune and epithelial cells, influencing cytokine production and tissue homeostasis signals.
As a short, structurally defined tripeptide, KPV is of interest in peptide science for its relative resistance to proteolytic degradation compared to longer peptide sequences, as well as for its potential utility as a research scaffold in melanocortin receptor pharmacology studies.
The areas where this compound appears in the published research literature.
In laboratory research, KPV is commonly applied to cell lines expressing melanocortin receptors (including MC1R and MC3R) to assess binding affinity via radioligand competition assays and to measure downstream signaling responses such as cAMP accumulation and NF-kB pathway inhibition.
Preclinical inflammation models (including chemically induced colitis models in rodents) have been used to investigate the effects of KPV administration on histological markers of tissue inflammation, cytokine profiles in tissue homogenates, and disease activity indices. These studies provide data on in vivo pharmacodynamics under controlled experimental conditions.
Peptide chemistry studies have examined the stability of KPV under physiological pH and temperature conditions, characterizing its proteolytic resistance relative to longer alpha-MSH fragments and informing formulation strategies for research applications.
Lyophilized KPV should be stored at -20 °C in a sealed, desiccated vial away from direct light. The lyophilized tripeptide is stable under these conditions. For reconstituted solutions, prepare in sterile water or PBS at the desired concentration and use fresh or store short-term at 4 °C; for longer storage, aliquot and freeze at -80 °C.
As a small tripeptide, KPV is relatively stable in aqueous solution compared to larger peptides but should still be protected from repeated freeze-thaw cycling and prolonged exposure to elevated temperatures.
KPV (Lysine-Proline-Valine) for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $60. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
The current batch has a published third-party certificate of analysis, shown above. KPV is supplied as lyophilized powder, for laboratory and research use only, not for human consumption.
