Ipamorelin
Compounded in a licensed US 503A pharmacy 🇺🇸
Selective Receptor Research Peptide.
Ipamorelin is a selective pentapeptide growth hormone secretagogue that acts as a ghrelin receptor (GHS-R1a) agonist, investigated for its specificity toward GH release without significant co-stimulation of cortisol or prolactin pathways. Laboratory researchers study its receptor activation kinetics and downstream pituitary signaling in comparison to other GHRPs, using in vitro pituitary cell preparations and preclinical animal models. Its selectivity profile makes it a valuable tool compound for dissecting the ghrelin/GHS axis in endocrine research settings. Supplied as a lyophilized pentapeptide of high analytical purity for laboratory research use only. Reconstitute with bacteriostatic water under sterile conditions.
- 5mg vial
- High-purity research compound
- Stable lyophilized powder
- For laboratory use only
Independently verified by Freedom Diagnostics via HPLC and mass spec. Every vial carries a unique accession number you can look up directly with the lab.
- 2-day shipping nationwide, flat $12.50
- Plain, discreet packaging. No product names on the outside.
- Tracking emailed the moment your order ships.
About Ipamorelin
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) that selectively activates the growth hormone secretagogue receptor (GHSR-1a, also known as the ghrelin receptor). It was developed as a research tool to investigate the pituitary growth hormone axis with a high degree of receptor selectivity, distinguishing it from earlier GHS compounds that also stimulated ACTH and cortisol secretion.
In preclinical research, ipamorelin has been studied for its effects on pulsatile growth hormone release, its interactions with the hypothalamic-pituitary axis, and the downstream signaling cascades initiated by GHSR-1a activation. Its selectivity profile makes it particularly useful for researchers seeking to isolate GH-axis effects without confounding corticotroph stimulation.
Ipamorelin is a research compound used exclusively in laboratory settings. It is not approved for human therapeutic use, and all work involving this peptide must be conducted under appropriate institutional and regulatory oversight.
Buy Ipamorelin online
Ipamorelin is in stock and available to buy online from Optimum ReGen Peptides — a real American research-peptide company with a physical storefront in Medford, Oregon, not an anonymous overseas dropshipper. Priced from $45, every order ships within two business days, flat $12.50 nationwide, in plain discreet packaging with tracking.
As your Ipamorelin supplier we back every batch with a third-party certificate of analysis and compound in a licensed US 503A pharmacy. Vials are supplied lyophilized at analytical purity for laboratory and research use only, not for human consumption.
Researched For
Ipamorelin is used in binding and functional assays to study GHSR-1a receptor activation, downstream cAMP and calcium signaling, and receptor desensitization kinetics in pituitary cell models.
In animal models, researchers have studied how ipamorelin administration affects the amplitude and pattern of endogenous growth hormone secretory pulses, contributing to understanding of GHS pharmacodynamics.
Studies have examined the relationship between GHSR-1a stimulation by ipamorelin and subsequent liver IGF-1 production in rodent models, providing data on the pituitary-liver signaling axis.
Preclinical investigations have explored how repeated GHSR agonism influences markers of bone mineral density and lean tissue in animal models of aging or metabolic challenge.
Research has compared ipamorelin to GHRP-2 and GHRP-6 to characterize the differences in ACTH/cortisol co-stimulation, establishing ipamorelin as a selective GHS tool compound.
How It Is Studied
In pituitary cell culture assays, ipamorelin is applied at nanomolar concentrations to assess GH secretion via radioimmunoassay or ELISA. Selectivity against ACTH secretion is measured in parallel corticotroph preparations, establishing the compound's functional specificity profile.
In vivo rodent studies typically involve subcutaneous administration with serial blood sampling to characterize the GH secretory pulse. Pharmacokinetic/pharmacodynamic modeling is used to relate plasma ipamorelin concentrations to GH release profiles across dosing intervals.
Molecular studies use GHSR-1a-transfected cell lines to measure receptor binding affinity (Ki), functional cAMP accumulation, and beta-arrestin recruitment in order to understand ipamorelin's signaling bias relative to native ghrelin.
Specifications
| Form | Lyophilized powder |
|---|---|
| Purity | >= 99% (HPLC) |
| Molecular Formula | C38H49N9O5 |
| CAS Number | 170851-70-4 |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH2 |
| Molar Mass | 711.85 g/mol |
Storage & Handling
Store lyophilized ipamorelin at -20 C or below, protected from moisture and light. The lyophilized form is stable under these conditions for extended periods. Once reconstituted in bacteriostatic water or sterile saline, store at 4 C for short-term use (up to 2-4 weeks based on published stability data) or aliquot and store at -80 C for longer retention. Minimize freeze-thaw cycles, which can promote peptide aggregation. Document all reconstitution and storage conditions per laboratory quality standards.
Frequently Asked Questions
How does ipamorelin differ from GHRP-6 in research selectivity?+
What receptor does ipamorelin bind?+
Is ipamorelin the same as ipamorelin/CJC-1295 blend products?+
What is the typical research concentration range for ipamorelin in cell studies?+
How stable is ipamorelin after reconstitution?+
Related research compounds
