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For laboratory research. Sold in 1mg and 10mg sizes.
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For research use only. Not for human consumption.
IGF-1 LR3 (Insulin-like Growth Factor 1, Long Arg3) is a synthetic analog of human IGF-1 in which the glutamic acid at position 3 is replaced by arginine and a 13-amino acid extension is added to the N-terminus. These structural modifications markedly reduce binding to IGF-binding proteins (IGFBPs), resulting in a molecule with extended biological half-life relative to native IGF-1 in preclinical model systems. This property makes IGF-1 LR3 a valuable tool compound for research into IGF-1 receptor (IGF-1R) signaling.
In laboratory settings, IGF-1 LR3 is used to study downstream signaling networks including the PI3K/AKT/mTOR and MAPK/ERK pathways. Researchers apply the compound to cell culture systems to examine effects on cell proliferation, glucose uptake, protein synthesis signaling markers, and differentiation endpoints in muscle, adipose, and neural cell models.
IGF-1 LR3 is supplied as a lyophilized research peptide and is intended solely for laboratory research use by qualified scientists. The extended half-life relative to native IGF-1 makes it useful in experimental designs requiring sustained receptor engagement, allowing researchers to study downstream signaling cascades without repeated compound additions.
The areas where this compound appears in the published research literature.
IGF-1 LR3 is most commonly applied in cell culture at low nanomolar concentrations (typically 1 to 100 ng/mL range in published studies). Researchers measure phosphorylation of AKT at Ser473, S6K1 at Thr389, and 4EBP1 at Thr37/46 as proximal readouts of mTORC1 pathway activation. Western blot with phospho-specific antibodies is the standard detection method.
IGF-1 LR3 is also studied in animal models. Its extended half-life relative to native IGF-1 means that receptor engagement is sustained for longer in in vivo designs. Researchers monitor body composition changes, organ mass indices, and tissue-specific gene expression profiles as study endpoints.
For IGFBP binding studies, researchers use competitive displacement assays comparing IGF-1 LR3 to native IGF-1 across a panel of binding proteins. This confirms the intended reduced-binding property of the analog and validates its utility as a tool for studying free IGF-1 receptor engagement without IGFBP-mediated buffering.
Lyophilized IGF-1 LR3 should be stored at -20 °C in a desiccated, light-protected environment. The powder remains stable for extended periods under these conditions. For reconstitution, researchers use 0.1% acetic acid or sterile phosphate-buffered saline containing 0.1% BSA to prevent adsorption to vessel surfaces; the specific vehicle is determined by the experimental protocol.
Reconstituted solution should be stored at 4 °C and used within 24 to 48 hours when prepared without BSA carrier, or within 7 days when BSA is included as a stabilizer. Single-use aliquots prepared before reconstitution minimize protein degradation from repeated freeze-thaw cycles.
IGF-1 LR3 (Long R3 IGF-1) for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $80. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
The current batch has a published third-party certificate of analysis, shown above. IGF-1 LR3 is supplied as lyophilized powder, for laboratory and research use only, not for human consumption.
