CJC-1295 (with DAC)
Compounded in a licensed US 503A pharmacy 🇺🇸
Extended Release Research Peptide.
CJC-1295 with DAC (Drug Affinity Complex) is a synthetic GHRH analogue engineered with a lysine-maleimide linker that covalently binds to serum albumin, substantially extending its circulating half-life compared to native GHRH. Researchers study this compound in growth hormone secretagogue research, investigating receptor binding kinetics, pulsatile GH release patterns, and downstream IGF-1 signaling in preclinical models. Its prolonged activity profile makes it a useful tool compound for longitudinal in vitro and in vivo laboratory studies on the somatotropic axis. Supplied as a lyophilized peptide of high analytical purity for research use only. Store at -20 degrees C and reconstitute under aseptic laboratory conditions.
- 2mg vial
- DAC-modified structure
- Research-only compound
Independently verified by Freedom Diagnostics via HPLC and mass spec. Every vial carries a unique accession number you can look up directly with the lab.
- 2-day shipping nationwide, flat $12.50
- Plain, discreet packaging. No product names on the outside.
- Tracking emailed the moment your order ships.
About CJC-1295 (with DAC)
CJC-1295 with DAC (Drug Affinity Complex) is a synthetic analog of growth hormone-releasing hormone (GHRH) that has been modified to extend its circulatory half-life. The DAC modification employs a maleimido-propionamide group that forms a covalent bond with serum albumin, dramatically prolonging the compound's residence time in biological systems compared to unmodified GHRH analogs.
In research models, CJC-1295 with DAC has been studied for its ability to stimulate growth hormone (GH) secretion from somatotroph cells of the anterior pituitary. The extended half-life allows investigators to examine sustained GHRH receptor activation and its downstream effects on GH and insulin-like growth factor 1 (IGF-1) levels over prolonged experimental windows.
Laboratory and preclinical studies have used this compound as a pharmacological tool to explore the GHRH axis, GH pulsatility, and the downstream anabolic and metabolic signaling cascades associated with chronic GH pathway stimulation.
Buy CJC-1295 (with DAC) online
CJC-1295 (with DAC) is in stock and available to buy online from Optimum ReGen Peptides — a real American research-peptide company with a physical storefront in Medford, Oregon, not an anonymous overseas dropshipper. Priced from $60, every order ships within two business days, flat $12.50 nationwide, in plain discreet packaging with tracking.
As your CJC-1295 (with DAC) supplier we back every batch with a third-party certificate of analysis and compound in a licensed US 503A pharmacy. Vials are supplied lyophilized at analytical purity for laboratory and research use only, not for human consumption.
Researched For
CJC-1295 with DAC has been studied extensively as a GHRH analog to investigate the regulation of GH secretion and the pituitary's responsiveness to sustained receptor stimulation in preclinical models.
Researchers have used CJC-1295 with DAC to examine how chronic GHRH receptor activation influences hepatic IGF-1 production and downstream anabolic signaling cascades in research settings.
The DAC modification that enables albumin binding has been a subject of pharmacokinetic research, with studies investigating half-life extension as a design strategy for peptide-based GHRH analogs.
Preclinical studies have investigated how sustained GH pathway activation by CJC-1295 with DAC influences parameters such as lean mass, adipose tissue distribution, and nitrogen balance in animal models.
Investigators have studied the metabolic effects of GH axis modulation via CJC-1295 with DAC, examining glucose homeostasis and lipid metabolism endpoints in controlled preclinical experiments.
How It Is Studied
In laboratory research, CJC-1295 with DAC is commonly administered to rodent models at defined intervals, after which blood samples are collected and assayed for GH and IGF-1 concentrations via ELISA. The long half-life conferred by DAC allows researchers to design dosing regimens that produce stable, sustained elevations in GHRH receptor engagement rather than acute pulses.
In vitro studies use primary pituitary cell cultures or somatotroph cell lines to examine receptor binding kinetics, cAMP signaling downstream of GHRH receptor activation, and GH secretion dynamics following CJC-1295 with DAC exposure.
Pharmacokinetic studies have characterized the albumin-binding behavior of the DAC modification using radiolabeled and fluorescently tagged versions of the compound, providing quantitative data on distribution, clearance, and effective half-life across species.
Specifications
| Form | Lyophilized powder |
|---|---|
| Purity | >= 99% (HPLC) |
| Molecular Formula | C165H269N47O46 |
| Molar Mass | 3647.15 g/mol |
| Storage | Store lyophilized at -20 °C; protect from light and moisture |
Storage & Handling
Lyophilized CJC-1295 with DAC should be stored at -20 °C in a sealed vial, protected from light and humidity. The lyophilized cake is stable under these conditions for extended periods. For working solutions, reconstitute in bacteriostatic water or sterile dilute acetic acid and store reconstituted aliquots at 4 °C for short-term use (typically up to 7 days) or at -80 °C for longer storage.
Repeated freeze-thaw cycles should be avoided as they can degrade peptide integrity. Aliquoting the reconstituted solution into single-experiment volumes prior to freezing is standard laboratory practice for preserving activity across multiple research sessions.
Frequently Asked Questions
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