0105 areas
Growth Hormone Axis Research
CJC-1295 with DAC has been studied extensively as a GHRH analog to investigate the regulation of GH secretion and the pituitary's responsiveness to sustained receptor stimulation in preclinical models.
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CJC‑1295 (with DAC)
For laboratory research. Sold in 2mg and 20mg kit sizes.
$41.40
$6031% off
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Lab sheet
CJC-1295 (with DAC), measured
Identity, purity and handling data for this compound, in one place. Tap an identifier to copy it.
Certificate of analysis
99.264%
HPLC purity, 2mg lot, reported 03/27/2026
Tested by Freedom Diagnostics, an independent lab. Search code Opti2603260288
View the certificateMolecular Formula
C165H269N47O46
Molar Mass
3647.15 g/mol
Form
Lyophilized powder
Full data sheet+
- Purity
- >= 99% (HPLC)
- Storage
- Store lyophilized at -20 °C; protect from light and moisture
For research use only. Not for human consumption.
Overview
About CJC-1295 (with DAC)
CJC-1295 with DAC (Drug Affinity Complex) is a synthetic analog of growth hormone-releasing hormone (GHRH) that has been modified to extend its circulatory half-life. The DAC modification employs a maleimido-propionamide group that forms a covalent bond with serum albumin, dramatically prolonging the compound's residence time in biological systems compared to unmodified GHRH analogs.
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In research models, CJC-1295 with DAC has been studied for its ability to stimulate growth hormone (GH) secretion from somatotroph cells of the anterior pituitary. The extended half-life allows investigators to examine sustained GHRH receptor activation and its downstream effects on GH and insulin-like growth factor 1 (IGF-1) levels over prolonged experimental windows.
Laboratory and preclinical studies have used this compound as a pharmacological tool to explore the GHRH axis, GH pulsatility, and the downstream anabolic and metabolic signaling cascades associated with chronic GH pathway stimulation.
Research context
What CJC-1295 (with DAC) is researched for
The areas where this compound appears in the published research literature.
Methodology
How CJC-1295 (with DAC) is studied
01Method 1In laboratory research, CJC-1295 with DAC is commonly administered to rodent models at defined intervals, after which blood samples are collected and assayed for GH and IGF-1 concentrations via ELISA.+
In laboratory research, CJC-1295 with DAC is commonly administered to rodent models at defined intervals, after which blood samples are collected and assayed for GH and IGF-1 concentrations via ELISA. The long half-life conferred by DAC allows researchers to study stable, sustained GHRH receptor engagement rather than acute pulses.
02Method 2In vitro studies use primary pituitary cell cultures or somatotroph cell lines to examine receptor binding kinetics, cAMP signaling downstream of GHRH receptor…+
In vitro studies use primary pituitary cell cultures or somatotroph cell lines to examine receptor binding kinetics, cAMP signaling downstream of GHRH receptor activation, and GH secretion dynamics following CJC-1295 with DAC exposure.
03Method 3Pharmacokinetic studies have characterized the albumin-binding behavior of the DAC modification using radiolabeled and fluorescently tagged versions of the…+
Pharmacokinetic studies have characterized the albumin-binding behavior of the DAC modification using radiolabeled and fluorescently tagged versions of the compound, providing quantitative data on distribution, clearance, and effective half-life across species.
Storage protocols
CJC-1295 (with DAC) storage and handling
Lyophilized
-20°C
Long-term storage, as supplied
Full handling protocol+
Lyophilized CJC-1295 with DAC should be stored at -20 °C in a sealed vial, protected from light and humidity. The lyophilized cake is stable under these conditions for extended periods. For working solutions, reconstitute in bacteriostatic water or sterile dilute acetic acid and store reconstituted aliquots at 4 °C for short-term use (typically up to 7 days) or at -80 °C for longer storage.
Repeated freeze-thaw cycles should be avoided as they can degrade peptide integrity. Aliquoting the reconstituted solution into single-experiment volumes prior to freezing is standard laboratory practice for preserving activity across multiple research sessions.
Ordering & shipping
Buy CJC-1295 (with DAC) online
CJC-1295 (with DAC) for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $60. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
The current batch has a published third-party certificate of analysis, shown above. CJC-1295 (with DAC) is supplied as lyophilized powder, for laboratory and research use only, not for human consumption.
FAQ
CJC-1295 (with DAC) FAQ
What does 'with DAC' mean in CJC-1295 with DAC?
DAC stands for Drug Affinity Complex, a maleimido-propionamide chemical modification that enables the peptide to form a covalent bond with serum albumin in biological fluids. This extends the compound's circulatory half-life significantly compared to native GHRH, which is a key design feature studied in pharmacokinetic research.
How does CJC-1295 with DAC differ from CJC-1295 without DAC?
CJC-1295 without DAC (also called Modified GRF 1-29) lacks the albumin-binding modification and has a substantially shorter half-life in biological systems. CJC-1295 with DAC is used when researchers want to study the effects of sustained GHRH receptor stimulation rather than acute, pulsatile activation.
What biological systems are studied using CJC-1295 with DAC?
Research using CJC-1295 with DAC primarily investigates the hypothalamic-pituitary GH axis, including GH secretion kinetics, IGF-1 production, and downstream anabolic and metabolic signaling. Studies are conducted in cell culture and preclinical animal models.
How is this compound supplied for research?
CJC-1295 with DAC is supplied as a lyophilized powder intended for laboratory use only. Researchers reconstitute it in appropriate solvents per their experimental protocols. It is not approved for human or veterinary use.
What assays are used to measure the research effects of CJC-1295 with DAC?
Common assays in research settings include ELISA-based measurement of serum GH and IGF-1, cAMP reporter assays in pituitary cell lines, and body composition analysis in preclinical models. Pharmacokinetic studies use labeled compound variants with techniques such as LC-MS/MS.
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