Chondrogenic differentiation
Cartilage-marker expression (SOX9, aggrecan, type II collagen, COMP) in aging mesenchymal stem cells.

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Three amino acids, H-Ala-Glu-Asp-OH, lyophilized. Sold in 20mg vials for laboratory research.
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For research use only. Not for human consumption.
Cartalax is a synthetic tripeptide, Ala-Glu-Asp (AED). It belongs to a family of short peptides, two to four amino acids long, that Vladimir Khavinson's group at the St. Petersburg Institute of Bioregulation and Gerontology studies for their effects on gene expression in cell-culture models of aging.
It has 3 amino acids (H-Ala-Glu-Asp-OH), a molecular formula of C12H19N3O8, a molar mass of 333.3 g/mol and CAS number 85806-95-7; the full identifiers are in the lab sheet above. ORP supplies it as a lyophilized powder for in vitro and preclinical research only. It is not for human or animal use and is not intended to diagnose, treat, cure, or prevent any disease.
In a 2023 study in Advances in Gerontology, AED was added to human mesenchymal stem cells undergoing replicative aging and increased gene expression and protein synthesis of the chondrogenic differentiation markers SOX9, aggrecan, type II collagen and COMP. A 2020 study in the Bulletin of Experimental Biology and Medicine compared AED with the dipeptide KE in human skin fibroblasts during replicative aging.
In a 2020 study in Molecular Biology Reports, AED, alongside the peptides KED and KE, was tested at nanomolar concentrations on the expression of genes linked to cell aging, including IGF1, FOXO1, TERT and NF-κB, in human mesenchymal stem cell cultures. A 2020 review from the same group lists AED among short peptides studied in neural and immune-cell differentiation.
Almost all published work on AED comes from this one research group and uses cell-culture models, so independent replication is limited. Its closest relative in this catalog is Epithalon, the tetrapeptide Ala-Glu-Asp-Gly (AEDG) from the same research program.
Researchers usually confirm identity against the sequence and a molar mass of about 333 by mass spectrometry, and purity by HPLC. A third-party certificate of analysis is not published here for this product; contact ORP before ordering if your work needs particular identity or purity tests.
The areas where this compound appears in the published research literature.
Published AED work uses human mesenchymal stem cell and skin fibroblast cultures, often comparing early and late passages to model replicative aging, with gene-expression and protein-synthesis readouts.
Identity is confirmed against the sequence H-Ala-Glu-Asp-OH and its molar mass by mass spectrometry, and purity by HPLC. Each research protocol sets its own model, controls, concentrations and handling; this listing supplies the compound, not a protocol.
Store lyophilized Cartalax at -20°C, sealed and protected from light and moisture. Let the vial reach room temperature before opening so moisture does not condense on the powder.
Reconstituted peptide solutions are commonly held at 2-8°C and divided into single-use aliquots to avoid repeated freeze-thaw cycles. Validate the solvent, concentration and use period for your own protocol.
Cartalax for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $80. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
Cartalax is supplied as lyophilized powder, for laboratory and research use only, not for human consumption.