0105 areas
NNMT Inhibition
5-Amino-1MQ has been investigated as a selective inhibitor of nicotinamide N-methyltransferase, with studies examining how NNMT blockade affects cellular metabolism in preclinical models.
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5‑Amino-1MQ
For laboratory research. Sold in 50mg and 500mg sizes.
$48.30
$7031% off
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Lab sheet
5-Amino-1MQ, measured
Identity, purity and handling data for this compound, in one place. Tap an identifier to copy it.
Certificate of analysis
99.82%
HPLC purity, 5mg lot, reported 07/06/2026
Tested by Freedom Diagnostics, an independent lab. Search code Opti2607020527
View the certificateMolecular Formula
C10H10N2
Molar Mass
162.20 g/mol
CAS Number
5765-44-6
Form
Lyophilized powder
Full data sheet+
- Purity
- >= 99% (HPLC)
- Storage
- Store lyophilized material at -20 °C, protected from light and moisture
For research use only. Not for human consumption.
Overview
About 5-Amino-1MQ
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in the regulation of cellular energy metabolism and NAD+ biosynthesis. Researchers have investigated this compound as a tool for modulating NNMT activity in in vitro and preclinical models, providing insight into the enzyme's role in metabolic homeostasis.
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In laboratory settings, 5-Amino-1MQ has been studied for its ability to reduce NNMT-mediated methylation of nicotinamide, which influences the availability of methyl groups and the cellular NAD+ pool. These properties make it a compound of significant interest in metabolic research and the study of adipogenesis pathways.
Research into 5-Amino-1MQ is conducted under controlled laboratory conditions. Scientists use it as a biochemical probe to better understand NNMT's contributions to lipid metabolism, mitochondrial function, and metabolic signaling networks.
Research context
What 5-Amino-1MQ is researched for
The areas where this compound appears in the published research literature.
Methodology
How 5-Amino-1MQ is studied
01Method 1In laboratory research, 5-Amino-1MQ is typically applied to cultured cell lines to assess changes in NNMT enzymatic activity via methyltransferase assays.+
In laboratory research, 5-Amino-1MQ is typically applied to cultured cell lines to assess changes in NNMT enzymatic activity via methyltransferase assays. Researchers measure downstream effects on NAD+ metabolite levels using LC-MS/MS methods and quantify lipid accumulation via fluorescent staining protocols.
02Method 2Preclinical studies have administered 5-Amino-1MQ in rodent dietary models to observe whole-body metabolic parameters, including body composition, energy expenditure, and plasma metabolite profiles.+
Preclinical studies have administered 5-Amino-1MQ in rodent dietary models to observe whole-body metabolic parameters, including body composition, energy expenditure, and plasma metabolite profiles. These studies help characterize the in vivo consequences of NNMT inhibition and inform further mechanistic research.
03Method 3Mechanistic investigations often pair 5-Amino-1MQ treatment with transcriptomic and proteomic analyses to map the downstream signaling changes that accompany…+
Mechanistic investigations often pair 5-Amino-1MQ treatment with transcriptomic and proteomic analyses to map the downstream signaling changes that accompany NNMT inhibition, establishing a fuller picture of the enzyme's regulatory network.
Storage protocols
5-Amino-1MQ storage and handling
Lyophilized
-20°C
Long-term storage, as supplied
Full handling protocol+
Lyophilized 5-Amino-1MQ should be stored at -20 °C in a sealed, desiccated container away from direct light. Reconstituted solutions are best prepared fresh in sterile solvent and used promptly; if storage of reconstituted material is necessary, aliquot into single-use volumes and keep at -80 °C to minimize freeze-thaw degradation.
Laboratory best practice calls for working with the compound in a low-humidity environment and minimizing exposure to oxidizing conditions. Stability data should be consulted for the specific solvent system used, as aqueous solutions may differ from DMSO stocks in long-term stability.
Ordering & shipping
Buy 5-Amino-1MQ online
5-Amino-1MQ (5-Amino-1-methylquinolinium) for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $70. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
The current batch has a published third-party certificate of analysis, shown above. 5-Amino-1MQ is supplied as lyophilized powder, for laboratory and research use only, not for human consumption.
FAQ
5-Amino-1MQ FAQ
What enzyme does 5-Amino-1MQ target in research?
5-Amino-1MQ is studied as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in NAD+ metabolism and methyl-group transfer reactions in cellular research models.
How is 5-Amino-1MQ used in laboratory studies?
Researchers apply 5-Amino-1MQ to cultured cells or preclinical animal models to investigate the metabolic consequences of NNMT inhibition, using assays that measure enzyme activity, NAD+ metabolites, and lipid profiles.
Is 5-Amino-1MQ available for human use?
5-Amino-1MQ is supplied strictly for laboratory research purposes. It is not approved for human or veterinary use, and all studies involving this compound are conducted under appropriate research protocols.
What solvents are used to reconstitute 5-Amino-1MQ for research?
In laboratory settings, 5-Amino-1MQ is commonly dissolved in DMSO to prepare stock solutions, which are then diluted in aqueous buffers to achieve working concentrations suitable for cell-based assays.
How does NNMT inhibition relate to NAD+ research?
NNMT consumes nicotinamide (a NAD+ precursor) via methylation; inhibiting this enzyme with compounds like 5-Amino-1MQ is studied as a way to redirect nicotinamide back into the NAD+ biosynthesis pathway, making it a useful probe in NAD+ metabolism research.
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