5-Amino-1MQ
Compounded in a licensed US 503A pharmacy 🇺🇸
NNMT Pathway Research Compound.
5-Amino-1MQ is a small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor researched in cellular metabolism and energy homeostasis models. Scientists investigate its role in modulating the methyl economy of the cell, particularly in adipocyte and metabolic tissue contexts. In laboratory settings it has been studied alongside NAD+ pathway components to assess downstream effects on mitochondrial function. Supplied as a laboratory-grade compound for in vitro and preclinical research use only. Handle under controlled conditions with appropriate protective equipment.
- NNMT pathway research compound
- High-purity laboratory grade
- Precision-measured format
- Research use only
Independently verified by Freedom Diagnostics via HPLC and mass spec. Every vial carries a unique accession number you can look up directly with the lab.
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About 5-Amino-1MQ
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in the regulation of cellular energy metabolism and NAD+ biosynthesis. Researchers have investigated this compound as a tool for modulating NNMT activity in in vitro and preclinical models, providing insight into the enzyme's role in metabolic homeostasis.
In laboratory settings, 5-Amino-1MQ has been studied for its ability to reduce NNMT-mediated methylation of nicotinamide, which influences the availability of methyl groups and the cellular NAD+ pool. These properties make it a compound of significant interest in metabolic research and the study of adipogenesis pathways.
Research into 5-Amino-1MQ is conducted under controlled laboratory conditions. Scientists use it as a biochemical probe to better understand NNMT's contributions to lipid metabolism, mitochondrial function, and metabolic signaling networks.
Buy 5-Amino-1MQ online
5-Amino-1MQ (5-Amino-1-methylquinolinium) is in stock and available to buy online from Optimum ReGen Peptides — a real American research-peptide company with a physical storefront in Medford, Oregon, not an anonymous overseas dropshipper. Priced from $50, every order ships within two business days, flat $12.50 nationwide, in plain discreet packaging with tracking.
As your 5-Amino-1MQ supplier we back every batch with a third-party certificate of analysis and compound in a licensed US 503A pharmacy. Vials are supplied lyophilized at analytical purity for laboratory and research use only, not for human consumption.
Researched For
5-Amino-1MQ has been investigated as a selective inhibitor of nicotinamide N-methyltransferase, with studies examining how NNMT blockade affects cellular metabolism in preclinical models.
Research has explored how inhibiting NNMT with 5-Amino-1MQ influences nicotinamide recycling and the cellular availability of NAD+ precursors in laboratory cell cultures.
Studies have used 5-Amino-1MQ to examine NNMT's involvement in lipid accumulation and adipocyte differentiation processes in vitro.
Investigators have studied how 5-Amino-1MQ treatment affects mitochondrial respiration and ATP production in laboratory-based cellular models.
The compound has served as a biochemical tool to probe how NNMT activity intersects with insulin signaling and glucose utilization pathways in research settings.
How It Is Studied
In laboratory research, 5-Amino-1MQ is typically applied to cultured cell lines to assess changes in NNMT enzymatic activity via methyltransferase assays. Researchers measure downstream effects on NAD+ metabolite levels using LC-MS/MS methods and quantify lipid accumulation via fluorescent staining protocols.
Preclinical studies have administered 5-Amino-1MQ in rodent dietary models to observe whole-body metabolic parameters, including body composition, energy expenditure, and plasma metabolite profiles. These studies help characterize the in vivo consequences of NNMT inhibition and inform further mechanistic research.
Mechanistic investigations often pair 5-Amino-1MQ treatment with transcriptomic and proteomic analyses to map the downstream signaling changes that accompany NNMT inhibition, establishing a fuller picture of the enzyme's regulatory network.
Specifications
| Form | Lyophilized powder |
|---|---|
| Purity | >= 99% (HPLC) |
| Molecular Formula | C10H10N2 |
| CAS Number | 5765-44-6 |
| Molar Mass | 162.20 g/mol |
| Storage | Store lyophilized material at -20 °C, protected from light and moisture |
Storage & Handling
Lyophilized 5-Amino-1MQ should be stored at -20 °C in a sealed, desiccated container away from direct light. Reconstituted solutions are best prepared fresh in sterile solvent and used promptly; if storage of reconstituted material is necessary, aliquot into single-use volumes and keep at -80 °C to minimize freeze-thaw degradation.
Laboratory best practice calls for working with the compound in a low-humidity environment and minimizing exposure to oxidizing conditions. Stability data should be consulted for the specific solvent system used, as aqueous solutions may differ from DMSO stocks in long-term stability.
Frequently Asked Questions
What enzyme does 5-Amino-1MQ target in research?+
How is 5-Amino-1MQ used in laboratory studies?+
Is 5-Amino-1MQ available for human use?+
What solvents are used to reconstitute 5-Amino-1MQ for research?+
How does NNMT inhibition relate to NAD+ research?+
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