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For laboratory research. Sold in 10mg and 100mg sizes.
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For research use only. Not for human consumption.
Semax is a heptapeptide analog of the ACTH(4-7) fragment with the sequence Met-Glu-His-Phe-Pro-Gly-Pro. Developed in Russia at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax was designed to retain the cognitive and neuroprotective properties associated with ACTH-derived peptides while eliminating their steroidogenic activity. It has been studied extensively in neuroscience research contexts.
Laboratory investigations have characterized Semax's interactions with the brain-derived neurotrophic factor (BDNF) signaling pathway. In rodent model studies, Semax exposure has been associated with increased BDNF and TrkB mRNA expression in hippocampal and cortical tissue, placing it within the growing field of neurotrophic factor research. Researchers have also examined its reported modulation of dopaminergic and serotonergic markers in preclinical neural models.
Semax is available for laboratory research as a lyophilized powder. Researchers who use intranasal delivery models find Semax of particular interest due to its small size and the research literature documenting its CNS-relevant pharmacokinetic properties in preclinical studies. All use is confined to laboratory research settings by trained scientific personnel.
The areas where this compound appears in the published research literature.
Semax is studied in rodent models across a range of research designs. Intranasal delivery models are of particular research interest given the compound's small molecular size and the desire to model CNS-targeted delivery approaches. Post-administration brain tissue is collected for BDNF ELISA, RT-PCR, and immunohistochemical analysis.
In vitro, Semax is applied to primary cortical neuron cultures and neural stem cell preparations. Researchers measure neuronal survival following oxidative stress or excitotoxic challenge using MTT/resazurin viability assays, caspase activation profiling, and mitochondrial membrane potential indicators. TrkB pathway phosphorylation status is assessed by Western blot.
Rodent behavioral studies complement biochemical endpoints. Researchers use standardized paradigms to quantify performance across treatment groups, and statistical analysis includes ANOVA with post-hoc correction. Semax's effect duration in behavioral models is a specific focus of pharmacodynamic research investigating the relationship between peripheral administration timing and CNS endpoint windows.
Lyophilized Semax powder should be stored at -20 °C in a sealed, desiccated container away from light and moisture. Under these conditions it maintains stability for the labeled shelf-life period. Once reconstituted in sterile saline or phosphate-buffered saline, the solution should be kept at 4 °C and used within 5 to 7 days.
For research workflows requiring multiple time-points, pre-aliquoting prior to reconstitution minimizes degradation risk. Researchers should document reconstitution concentration, vehicle, and date. Discard any solution that becomes cloudy or develops particulate matter.
Semax for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $60. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
The current batch has a published third-party certificate of analysis, shown above. Semax is supplied as lyophilized powder, for laboratory and research use only, not for human consumption.
