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A nine-amino-acid peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, lyophilized. Sold in 10mg vials for laboratory research.
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A third-party certificate for DSIP is not published here yet. If your work needs one, ask us before ordering and we will tell you what testing is available for the current lot.
Ask about a certificateFor research use only. Not for human consumption.
DSIP, or delta sleep-inducing peptide, is a nonapeptide research compound with the published sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (CAS 62568-57-4, molecular formula C35H48N10O15). It is supplied to laboratories as a lyophilized powder for in vitro and preclinical research use only, not for human consumption, and is not intended to diagnose, treat, cure, or prevent any disease. Because DSIP is small, water-soluble, and structurally well characterized, it functions in many studies as a reference peptide for examining neuropeptide behavior in blood and cerebrospinal fluid research models.
The name delta sleep-inducing peptide reflects the peptide's original 1974 characterization by Monnier and colleagues, whose electrical-stimulation studies in rabbits linked cerebral venous extracts to delta-wave, or slow-wave, EEG activity associated with deep non-REM sleep stages. Subsequent laboratory work has focused less on reproducing that original observation and more on mapping how DSIP interacts with the systems that regulate circadian and ultradian rhythm in animal research models. Researchers frequently note that the sleep-inducing portion of the name describes the historical research context of its discovery rather than a demonstrated effect in any species, including humans.
DSIP peptide research today is concentrated in a handful of recurring model systems: rodent EEG and sleep-stage recording, isolated hypothalamic-pituitary tissue and cell-culture assays, and plasma stability and protein-binding studies. Much of the published literature approaches DSIP less as a single-mechanism peptide and more as a signaling molecule with multiple, still-debated points of interaction across the neuroendocrine system. This breadth is part of why DSIP continues to appear in comparative-peptide panels alongside other short neuropeptides studied for hypothalamic and pituitary signaling.
Documented DSIP research applications include studies of opioid-tolerance and withdrawal models, stress-response and gastric stress-ulcer models in rodents, chronobiology and circadian-rhythm research, and early radioprotection studies examining peptide behavior under radiation exposure in animal tissue. Each of these lines of investigation uses DSIP as a tool compound to probe a specific physiological pathway rather than as a single-purpose research subject. Researchers comparing findings across these application areas typically note that DSIP's effects appear model-dependent, varying with concentration, tissue type, and experimental timing in ways that are still being mapped in the literature.
Proposed research mechanisms for DSIP include modulation of GABA-ergic signaling, interaction with hypothalamic-pituitary-adrenal (HPA) axis regulation, and a possible role in growth-hormone secretion pathways, alongside its previously noted capacity to cross the blood-brain barrier under certain experimental conditions. None of these mechanisms is fully established; the peptide research literature describes them as competing hypotheses rather than a settled mode of action. This mechanistic ambiguity is itself a reason DSIP remains an active subject of comparative neuropeptide research.
DSIP reconstitution for laboratory use typically involves adding bacteriostatic or sterile water slowly down the interior wall of the vial, then swirling gently rather than shaking, since agitation can shear the peptide's structure. Reconstituted DSIP is generally kept refrigerated at 2-8°C and used within the timeframe defined by the receiving lab's protocol, with repeat freeze-thaw cycles avoided because they degrade peptide integrity over time. This reconstitution guidance describes laboratory handling procedure only; it is not administration or dosing guidance for humans or animals.
Before ordering DSIP for laboratory research, review its documented identity and available batch-specific test results. Contact us for batch documentation; a published report should be checked against the product and lot you are considering.
The areas where this compound appears in the published research literature.
Classical DSIP research employs EEG telemetry in freely moving rodents or rabbits, with continuous electrophysiological recording used to quantify changes in sleep architecture following peptide administration. Power spectral analysis of EEG frequency bands allows researchers to objectively characterize delta, theta, and spindle activity in treated versus control animals.
HPA axis studies measure serum cortisol, ACTH, and CRH levels via radioimmunoassay or ELISA following DSIP administration in stress-challenged animal models. Researchers examine dose-response relationships and time-course effects to characterize how the peptide interacts with the stress hormone cascade under controlled laboratory conditions.
Neuroendocrine experiments use pituitary cell cultures (GH3, AtT-20) and primary pituitary tissue explants to measure peptide release in response to DSIP. Mass spectrometry-based peptide profiling and protein expression panels help researchers map DSIP's interactions with hormone-secreting cell populations at the molecular level.
Lyophilized DSIP should be stored at -20°C in a desiccated, light-protected environment. Under proper cold storage, the peptide remains stable over extended research timelines. Vials should be equilibrated to room temperature under desiccant before opening to prevent moisture condensation.
Reconstituted DSIP solutions for laboratory use should be held at 4°C and consumed within 24 to 48 hours. Researchers are advised to prepare small working aliquots to avoid repeated temperature cycling, which can accelerate degradation of the peptide structure.
DSIP (Delta Sleep-Inducing Peptide) for sale from Optimum ReGen Peptides, a US research-peptide company with a storefront in Medford, Oregon. It is in stock, priced from $60. Every order ships 2-Day Priority Air, a $13 flat rate anywhere in the US, with tracking, or can be picked up at the store.
DSIP is supplied as lyophilized powder, for laboratory and research use only, not for human consumption.
