Selank
Compounded in a licensed US 503A pharmacy 🇺🇸
Peptide Research Compound.
Selank is a synthetic heptapeptide analogue of the endogenous immunomodulatory tetrapeptide Tuftsin (Thr-Lys-Pro-Arg), studied in neuropharmacology and neurotransmitter pathway research. Laboratory researchers investigate its effects on GABA-A receptor modulation, BDNF expression, and monoamine neurotransmitter balance in neuronal cell cultures and preclinical animal models. It is also studied for its enzymatic stability and peptidase resistance in plasma stability assays, making it useful as a model compound in CNS peptide research. Supplied as a lyophilized peptide of analytical purity for laboratory investigation only. Handle under sterile conditions; store refrigerated.
- 5mg format
- High purity
- Laboratory use only
Independently verified by Freedom Diagnostics via HPLC and mass spec. Every vial carries a unique accession number you can look up directly with the lab.
- 2-day shipping nationwide, flat $12.50
- Plain, discreet packaging. No product names on the outside.
- Tracking emailed the moment your order ships.
About Selank
Selank is a synthetic heptapeptide analog of the endogenous immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg), developed in Russia at the Institute of Molecular Genetics. With the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, Selank was designed to combine tuftsin-like biological activity with enhanced metabolic stability, as the Pro-Gly-Pro C-terminal extension confers resistance to proteolytic degradation.
In laboratory and preclinical research, Selank has been investigated for its effects on anxiolytic-like behavior in animal models, as well as for its interactions with the GABAergic system, brain-derived neurotrophic factor (BDNF) expression, and enkephalin metabolism. Research has also examined its putative immunomodulatory properties in the context of its tuftsin-derived sequence.
Selank represents a research model for studying the intersection of neuropeptide pharmacology and immune modulation, and has served as a tool in preclinical neuroscience to probe anxiety-related circuitry and peptidergic modulation of CNS function.
Buy Selank online
Selank is in stock and available to buy online from Optimum ReGen Peptides — a real American research-peptide company with a physical storefront in Medford, Oregon, not an anonymous overseas dropshipper. Priced from $60, every order ships within two business days, flat $12.50 nationwide, in plain discreet packaging with tracking.
As your Selank supplier we back every batch with a third-party certificate of analysis and compound in a licensed US 503A pharmacy. Vials are supplied lyophilized at analytical purity for laboratory and research use only, not for human consumption.
Researched For
Selank has been studied in rodent anxiety models (elevated plus maze, open field test) to characterize its effects on anxiety-related behavioral endpoints, with investigators examining its interaction with GABA receptor systems.
Laboratory studies have investigated how Selank influences brain-derived neurotrophic factor (BDNF) expression in neuronal cell cultures and rodent brain regions, contributing to research on neuropeptide regulation of neurotrophic signaling.
Research has examined Selank's effects on the activity of enkephalin-degrading enzymes (enkephalinases), suggesting a potential mechanism for extending the activity of endogenous opioid peptides in preclinical models.
As a tuftsin analog, Selank has been studied for effects on innate immune cell function, including macrophage activation and cytokine expression, in laboratory immunology models.
Selank is used as a research tool to investigate how synthetic neuropeptide analogs interact with central nervous system signaling networks, including serotonergic and dopaminergic systems, in preclinical preparations.
How It Is Studied
Preclinical behavioral pharmacology studies administer Selank to rodents via intranasal or parenteral routes and assess behavioral outcomes using standardized anxiety-related paradigms such as the elevated plus maze, light-dark box, and open field test. Researchers measure time in open arms, locomotor activity, and rearing behavior as quantitative endpoints.
Neurobiological studies examine Selank's effects on gene and protein expression in brain tissue, quantifying BDNF, GABA receptor subunit levels, and enkephalin-degrading enzyme activity via RT-PCR, Western blot, and fluorometric enzyme assays. These studies map the molecular correlates of observed behavioral effects.
In vitro studies apply Selank to cultured neuronal cells and immune cells to characterize direct cellular effects independent of whole-organism pharmacokinetics, providing mechanistic data on receptor interactions and intracellular signaling responses.
Specifications
| Form | Lyophilized powder |
|---|---|
| Purity | >= 99% (HPLC) |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Molecular Formula | C33H57N11O9 |
| CAS Number | 129954-34-3 |
| Molar Mass | 751.88 g/mol |
Storage & Handling
Lyophilized Selank should be stored at -20 °C in a sealed vial away from direct light and humidity. The lyophilized peptide is stable under these conditions for extended periods. Reconstituted solutions should be prepared in sterile bacteriostatic water or physiological saline and used promptly for research assays.
If reconstituted Selank must be stored between experimental sessions, aliquot into single-use volumes and freeze at -80 °C to minimize degradation. The Pro-Gly-Pro C-terminal extension provides some proteolytic resistance in solution, but peptide integrity should be periodically verified by HPLC for long-term research projects.
Frequently Asked Questions
What is the structural relationship between Selank and tuftsin?+
What animal models are used in Selank research?+
How does Selank relate to the GABAergic system in research?+
Is Selank approved for any medical use?+
How is Selank's effect on BDNF studied in the laboratory?+
Related research compounds
