BPC-157 (Body Protection Compound-157) is a pentadecapeptide consisting of 15 amino acids, derived from a partial sequence of human gastric juice protein BPC. It was first described in the early 1990s, and since then has been extensively studied in preclinical models for its effects on tissue repair, angiogenesis, and gastrointestinal function.
A substantial body of peer-reviewed research, largely conducted in rodent models, has investigated BPC-157's interactions with the nitric oxide (NO) system, growth hormone receptors, and vascular endothelial growth factor (VEGF) pathways. These studies have examined its stability in gastric acid and its systemic availability following different routes of administration in controlled laboratory settings.
BPC-157 has attracted significant scientific attention due to its apparent multi-tissue activity in research models, with studies spanning tendon, muscle, bone, nerve, and gastrointestinal tissue. Its mechanism of action remains an active area of investigation, with researchers exploring interactions between this peptide and multiple signaling networks involved in cellular repair and cytoprotection.